Antinociception induced by chronic exposure of rats to cigarette smoke
Antinociception induced by chronic exposure of rats to cigarette smoke
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DOI：
10.1016/j.neulet.2004.05.020
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发表时间：
2004-08-05
影响因子：
2.5
通讯作者：
Carstens, E
中科院分区：
文献类型：
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作者：
Anderson, KL;Pinkerton, KE;Carstens, E
为了研究长期暴露于香烟烟雾是否会导致镇痛，研究人员将大鼠置于一个环境室中，连续4天（每天6小时）暴露于集中的香烟烟雾中，间隔2天无烟。对照组暴露在室内空气中。在每个烟雾暴露时段，甩尾潜伏期显著增加（镇痛），在不同时段的镇痛相对下降（耐受性），并在前三个无烟间隔期间恢复到控制水平，而在4周暴露期结束后仍保持较高水平。烟雾暴露组和对照组的机械（von Frey）戒断阈值随着时间的推移而下降，烟雾暴露组的阈值明显降低。在每周吸烟结束时，血浆尼古丁达到95.4 +/- 32 (S.D.) ng/ml，停烟后24 h降至44.9 +/- 10.6 ng/ml。大鼠在吸烟期间体重减轻，在无烟间隔期和停止吸烟期间体重迅速恢复。镇痛作用可能有助于开始吸烟，急性暴露后镇痛作用的迅速逆转可能导致戒烟困难。2004爱思唯尔爱尔兰有限公司版权所有。
To investigate if chronic exposure to cigarette smoke induces analgesia, rats were exposed to concentrated cigarette smoke in an environmental chamber over four successive 5-day blocks (6 h/day), with 2 smoke-free days between blocks. A control group was exposed to room air. Tail flick latencies increased significantly (analgesia) during each smoke exposure block, with a relative decline in analgesia across blocks (tolerance) and a return to control levels during the first three smoke-free interludes while remaining higher after the conclusion of the 4-week exposure period. Mechanical (von Frey) withdrawal thresholds declined over time in smoke-exposed and control groups, with the smoke-exposed group showing significantly lower thresholds. Plasma nicotine reached 95.4 +/- 32 (S.D.) ng/ml at the end of weekly smoke exposure and declined to 44.9 +/- 10.6 ng/ml 24 h after withdrawal. Rats lost weight during smoke exposure and quickly regained weight during smoke-free interludes and at the cessation of smoke exposure. Analgesia may contribute to the initiation of smoking, and rapid reversal of the analgesic effect following acute exposure may contribute to the difficulty in quitting smoking. (C) 2004 Elsevier Ireland Ltd. All rights reserved.