A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China.
A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China.
复制标题
基于人群的症状定义胃食管反流病流行病学调查：中国胃肠道疾病的系统调查
DOI：
10.1186/1471-230x-10-94
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发表时间：
2010-08-15
影响因子：
2.4
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
He J;Ma X;Zhao Y;Wang R;Yan X;Yan H;Yin P;Kang X;Fang J;Hao Y;Li Q;Dent J;Sung JJ;Zou D;Wallander MA;Johansson S;Liu W;Li Z
背景胃食道反流病(GERD)的流行病学尚未采用蒙特利尔定义推荐的症状性阈值标准进行调查。本研究旨在了解中国地区5个地区的症状性胃肠反流病的患病率，并调查与胃肠道反流性疾病相关的变量。方法从各地区的农村和城市平均抽取18000名18-80岁的成年人作为样本。根据蒙特利尔定义，每周2天≥出现轻度烧心和/或反流症状，或每周1天≥出现中到重度烧心和/或反流症状时，即为胃肠道反流。根据蒙特利尔标准，症状定义的胃肠道反流病的患病率为3.1%，在五个地区(从广州的1.7%到武汉的5.1%)以及城乡人口之间(3.8%和2.4%)有显著差异(p<；0.001)。居住在农村和有胃肠道疾病家族史与胃肠反流性疾病显著相关。结论本次人群调查发现中国地区症状性胃肠反流病的患病率为3.1%，低于西方国家。
BackgroundThe epidemiology of gastroesophageal reflux disease (GERD) has yet to be investigated using the symptomatic threshold criteria recommended by the Montreal Definition. This study aimed to determine the prevalence of symptom-defined GERD across five regions of China, and to investigate variables associated with GERD.MethodsA representative sample of 18 000 adults (aged 18-80 years) were selected equally from rural and urban areas in each region (n = 1800). According to the Montreal Definition, GERD is present when mild symptoms of heartburn and/or regurgitation occur on ≥2 days a week, or moderate-to-severe symptoms of heartburn and/or regurgitation occur on ≥1 day a week.ResultsIn total, 16 091 participants completed the survey (response rate: 89.4%) and 16 078 responses were suitable for analysis. Applying the Montreal criteria, the prevalence of symptom-defined GERD was 3.1% and varied significantly (p< 0.001) among the five regions (from 1.7% in Guangzhou to 5.1% in Wuhan) and between rural and urban populations (3.8% vs 2.4%). Factors significantly associated with GERD included living in a rural area and a family history of gastrointestinal diseases.ConclusionsThis population-based survey found that the prevalence of symptom-defined GERD in China was 3.1%, which is lower than that found in Western countries.