The Feasibility of Magnetic Resonance Imaging for Quantification of Liver, Pancreas, Spleen, Vertebral Bone Marrow, and Renal Cortex R2* and Proton Density Fat Fraction in Transfusion-Related Iron Overload.
The Feasibility of Magnetic Resonance Imaging for Quantification of Liver, Pancreas, Spleen, Vertebral Bone Marrow, and Renal Cortex R2* and Proton Density Fat Fraction in Transfusion-Related Iron Overload.
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DOI：
10.4274/tjh.2015.0142
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发表时间：
2016-03-05
期刊：
影响因子：
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通讯作者：
Karçaaltıncaba M
中科院分区：
文献类型：
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作者：
İdilman İS;Gümrük F;Haliloğlu M;Karçaaltıncaba M
我们的目的是评估量化肝脏，胰腺，脾脏，脊椎骨髓，肾皮质R2* 和磁共振成像质子密度脂肪分数（MRI-PDFF）的可行性，并评估它们之间的相关性在输血相关的铁过载患者。本研究共纳入了9例因疑似肝铁超载而转诊至我们诊所的患者（5例男孩，4例女孩）。所有患者均接受T1非依赖性容积多回波梯度回波成像，T2* 校正和频谱脂肪建模。在1.5 T MRI系统上进行MRI检查。所有患者均存在肝脏铁超载。在5/9例患者（56%）中记录了严重的肝脏铁过载，当我们评价这些患者的PDFF图时，我们在5例患者中的4例中观察到肝脏中的广泛斑片状伪影（R2* 大于671 Hz）。尽管存在这些伪影，但当我们进行MRI-PDFF测量时，我们观察到伪影高MRI-PDFF值。平均胰腺R2* 与平均胰腺MRI-PDFF之间存在密切相关性（p=0.003，r=0.860）。肝脏R2* 与平均胰腺R2*（p=0.021，r=0.747）、肝脏R2* 与肾皮质R2*（p=0.020，r=0.750）以及平均胰腺R2* 与肾皮质R2*（p=0.003，r=0.858）之间存在显著相关性。椎体骨髓R2* 与年龄呈显著负相关（p=0.018，r=-0.759）。肝脏的高铁含量，特别是T2* 值短于第一个回波时间，可能会破坏PDFF计算的有效性。胰腺中的脂肪沉积伴随着胰腺铁超负荷。肝铁质沉着症和胰腺铁质沉着症之间有显著的相关性。肾皮质和胰腺铁质沉着症也是相关的。
We aimed to evaluate the feasibility of quantification of liver, pancreas, spleen, vertebral bone marrow, and renal cortex R2* and magnetic resonance imaging-proton density fat fraction (MRI-PDFF) and to evaluate the correlations among them in patients with transfusion-related iron overload. A total of 9 patients (5 boys, 4 girls) who were referred to our clinic with suspicion of hepatic iron overload were included in this study. All patients underwent T1-independent volumetric multi-echo gradient-echo imaging with T2* correction and spectral fat modeling. MRI examinations were performed on a 1.5 T MRI system. All patients had hepatic iron overload. Severe hepatic iron overload was recorded in 5/9 patients (56%), and when we evaluated the PDFF maps of these patients, we observed an extensive patchy artifact in the liver in 4 of 5 patients (R2* greater than 671 Hz). When we performed MRI-PDFF measurements despite these artifacts, we observed artifactual high MRI-PDFF values. There was a close correlation between average pancreas R2* and average pancreas MRI-PDFF (p=0.003, r=0.860). There was a significant correlation between liver R2* and average pancreas R2* (p=0.021, r=0.747), liver R2* and renal cortex R2* (p=0.020, r=0.750), and average pancreas R2* and renal cortex R2* (p=0.003, r=0.858). There was a significant negative correlation between vertebral bone marrow R2* and age (p=0.018, r=-0.759). High iron content of the liver, especially with a T2* value shorter than the first echo time can spoil the efficacy of PDFF calculation. Fat deposition in the pancreas is accompanied by pancreatic iron overload. There is a significant correlation between hepatic siderosis and pancreatic siderosis. Renal cortical and pancreatic siderosis are correlated, too.