Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application.
Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application.
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小核仁 RNA 有潜力成为白血病发生和临床应用的新参与者
DOI：
10.1097/bs9.0000000000000091
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Wang WT
中科院分区：
文献类型：
--
作者：
Lin LM;Pan Q;Sun YM;Wang WT
白血病发生机制的不清楚阻碍了白血病的诊断、预后和治疗。研究发现，小核RNA（snoRNA）在白血病中起着重要作用。这些小的非编码RNA参与核糖体的生物合成，包括前体核糖体RNA（pre-rRNA）的2′-O-甲基化和假尿苷化，以及pre-rRNA的剪接。近年来，许多snoRNA被发现是孤儿RNA，没有可预测的RNA修饰靶点，但这些snoRNA被发现位于不同的亚细胞器中，发挥着不同的作用。使用高通量技术，snoRNA的表达谱已被揭示在白血病，和一些失调的snoRNA可能会调节白血病细胞的细胞周期，分化，增殖和凋亡，并在白血病治疗过程中赋予耐药性。在这篇综述中，我们讨论了snoRNA，特别是孤儿snoRNA，在白血病中的表达谱和功能。这些异常表达的snoRNA可能是白血病诊断和预后的标志物，并可能成为白血病治疗的潜在靶点。
Lack of clarity of the mechanisms that underlie leukemogenesis obstructs the diagnosis, prognosis, and treatment of leukemia. Research has found that small nuclear RNA (snoRNA) plays an essential role in leukemia. These small non-coding RNAs are involved in ribosome biogenesis, including the 2′-O-methylation and pseudouridylation of precursor ribosomal RNA (pre-rRNA), and pre-rRNA splicing. Recently, many snoRNAs were found to be orphans that have no predictable RNA modification targets, but these RNAs have always been found to be located in different subcellular organelles, and they play diverse roles. Using high-throughput technology, snoRNA expression profiles have been revealed in leukemia, and some of the deregulated snoRNAs may regulate the cell cycle, differentiation, proliferation, and apoptosis in leukemic cells and confer drug resistance during leukemia treatment. In this review, we discuss the expression profiles and functions of snoRNAs, particularly orphan snoRNAs, in leukemia. It is possible that the dysregulated snoRNAs are promising diagnosis and prognosis markers for leukemia, which may serve as potential therapeutic targets in leukemia treatment.