Development and differentiation of the erythroid lineage in mammals.
Development and differentiation of the erythroid lineage in mammals.
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DOI：
10.1016/j.dci.2015.12.012
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发表时间：
2016-05
影响因子：
2.9
通讯作者：
Baron MH
中科院分区：
文献类型：
--
作者：
Barminko J;Reinholt B;Baron MH
红细胞（RBC）负责执行高度专业化的氧气运输功能，使其在妊娠期和产后生活中至关重要。因此，建立足够的RBC数量已经发展成为植入后胚胎的主要优先事项。“原始”红细胞系是第一个在发育中的胚胎中被指定的。在整个妊娠期间，大量资源专门用于生产红细胞。在造血干细胞（HSCs）接管胎儿肝脏中产生“定形”RBC之前，在发育过程中观察到两个短暂且形态上不同的造血祖细胞衍生红细胞生成波。在妊娠末期，造血干细胞迁移到骨髓，成为成人红细胞产生的主要场所。红细胞生成在红系细胞成熟的各个阶段受到调节，以确保响应生理需求而产生足够的RBC。在这里，我们强调哺乳动物红系细胞发育和成熟的关键方面，以及原始和永久红系细胞谱系之间的差异。
The red blood cell (RBC) is responsible for performing the highly specialized function of oxygen transport, making it essential for survival during gestation and postnatal life. Establishment of sufficient RBC numbers, therefore, has evolved to be a major priority of the postimplantation embryo. The “primitive” erythroid lineage is the first to be specified in the developing embryo proper. Significant resources are dedicated to producing RBCs throughout gestation. Two transient and morphologically distinct waves of hematopoietic progenitor-derived erythropoiesis are observed in development before hematopoietic stem cells (HSCs) take over to produce “definitive” RBCs in the fetal liver. Toward the end of gestation, HSCs migrate to the bone marrow, which becomes the primary site of RBC production in the adult. Erythropoiesis is regulated at various stages of erythroid cell maturation to ensure sufficient production of RBCs in response to physiological demands. Here, we highlight key aspects of mammalian erythroid development and maturation as well as differences among the primitive and definitive erythroid cell lineages.