Low protein fouling synthetic membranes by UV-assisted surface grafting modification: varying monomer type
Low protein fouling synthetic membranes by UV-assisted surface grafting modification: varying monomer type
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DOI：
10.1016/j.memsci.2003.11.013
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发表时间：
2004-03
影响因子：
9.5
通讯作者：
M. Taniguchi;G. Belfort
中科院分区：
文献类型：
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作者：
M. Taniguchi;G. Belfort
光诱导接枝和聚合的敏感性以及六种不同接枝单体的过滤性能[2种中性（N-2-乙烯基吡咯烷酮（NVP）、2-甲基丙烯酸羟乙酯（HEMA））、2种弱（羧酸）酸（丙烯酸（AA）、2-丙烯酰氨基乙醇酸（AAG））和2种强酸 测量了聚醚砜（PES）膜上的（磺酸）酸（甲基丙烯酸3-磺基丙酯（SPMA）、2-丙烯酰氨基-2-甲基-1-丙磺酸（AMPS））]。该方法是 (i) 跟踪具有不同孔径 (10-300kDa) 的商用 PES 超滤膜的接枝程度，作为单体浓度乘以照射时间的函数（初始线性斜率称为“灵敏度”），(ii) 比较各种接枝膜 (PES-gr-单体) 的润湿性，作为接枝膜亲水性的量度。 (iii) 将其过滤性能（蛋白质保留、流体动力学阻力和清洁性）与磷酸盐缓冲溶液 (PBS) 中的 1g/l 蛋白质（牛血清白蛋白，BSA）进行对比。尽管所有接枝和聚合单体都比未改性的 PES 膜提高了 PES 接枝膜的表面润湿性，但它们对过滤性能的影响不同。使用 50kDa PES 膜进行接枝，通过 NVP、AMPS 和 AA 单体获得具有优越性能（高蛋白质保留、高蛋白质溶液通量和低不可逆污染）的膜。商业再生纤维素或 PES 膜都没有竞争力。然而，对于较大孔径的膜（70 和 100kDa），与对照膜相比，PES-gr-AMPS 和 PES-gr-AA 膜表现出相当高的 BSA 截留率和蛋白质溶液通量，以及出色的清洁能力（预计具有高长期性能）。 NVP 和 HEMA 的移植最初导致 BSA 排斥反应大幅下降，因为它们倾向于溶解 PES，但随着进一步移植，排斥反应又恢复了。与收到的商用 PES 膜相比，这两种单体还表现出接枝敏感性降低和总水阻力降低，并且润湿性（或接枝度，DG）增加。对于带电单体来说，接枝敏感性与单体尺寸[(摩尔体积)1/3]成反比。此外，还获得了 DG 与单体浓度乘以照射时间的复合参数的通用图，并且可用于预测。我们还提供了如何选择乙烯基单体使用接枝辅助光聚合制备高性能超滤膜的详细实验方案和新的品质因数以帮助比较修改。
The sensitivity of photo-induced grafting and polymerization and the filtration performance of six different grafted monomers [2 neutral (N-2-vinyl pyrolidinone (NVP), 2-hydroxyethyl methacrylate (HEMA)), 2 weak (carboxylic) acids (acrylic acid (AA), 2-acrylamidoglycolic acid (AAG)), and 2 strong (sulfonic) acids (3-sulfopropyl methacrylate (SPMA), 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS))] on poly(ether sulfone) (PES) membranes were measured. The approach was to (i) follow the degree of grafting on commercial PES ultrafiltration membranes with varying pore size (10–300kDa) as a function of monomer concentration multiplied by irradiation time (the initial linear slopes are termed “sensitivity”), (ii) compare the wettabilities of various grafted membranes (PES-gr-monomer) as a measure of the hydrophilicity of the grafted surfaces, and (iii) contrast their the filtration performances (protein retention, hydrodynamic resistance, and cleanability) with 1g/l protein (bovine serum albumin, BSA) in phosphate buffer solution (PBS). Although all the grafted and polymerized monomers increased the surface wettability of the PES-grafted membranes over that for the unmodified PES membranes, their effect on filtration performance was different. Using the 50kDa PES membranes for grafting, membranes with superior performance (high protein retention, high protein solution flux, and low irreversible fouling) were obtained with the NVP, AMPS and AA monomers. Neither commercial regenerated cellulose or PES membranes were as competitive. For larger pore-size membranes (70 and 100kDa), however, PES-gr-AMPS and PES-gr-AA membranes exhibited reasonably high BSA rejection and protein solution fluxes with excellent cleaning capability (with projected high long-term performance) as compared with the control membranes. Grafting of NVP and HEMA resulted in an initial substantial decrease in BSA rejection due to their tendency to dissolve PES, but with further grafting rejection was recovered. These two monomers also exhibited reduced grafting sensitivity and reduced total hydraulic resistance with increases in wettability (or degree of grafting, DG) as compared with the as-received commercial PES membrane. Grafting sensitivity was inversely proportional to monomer size [(molar volume)1/3] for the charged monomers. Also, universal plots of DG versus a composite parameter of monomer concentration multiplied by time of irradiation were obtained and can be used for prediction. We also provide a detailed experimental protocol of how to choose vinyl monomers for preparing high performance ultrafiltration membranes using graft-assisted photo-polymerization and a new figure-of-merit to help compare modifications.