Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp K07-0010
Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp K07-0010
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DOI：
10.1038/ja.2011.139
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发表时间：
2012-04-01
影响因子：
3.3
通讯作者：
Omura, Satoshi
中科院分区：
文献类型：
--
作者：
Hashida, Junko;Niitsuma, Megumi;Omura, Satoshi
从链霉菌K 07 -0010发酵液中分离纯化了两个新的异色满类化合物：panowamycin A和B，以及已知化合物NFAT-133、conglobatin、piericidin C系列和dinactin。通过包括各种NMR实验的光谱研究，将帕诺瓦霉素的结构阐明为NFAT-133的新类似物。帕诺瓦霉素A和B表现出中等程度的抗锥虫活性，IC 50值分别为0.40和3.30 μ g/ml。The Journal of Antibiotics（2012）65，197-202; doi：10.1038/ja.2011.139; 2012年1月25日在线发表
Two new isochromans, panowamycins A and B, were purified by solvent extraction, silica gel and octadecylsilyl silica gel (ODS) column chromatography followed by preparative HPLC, from a culture broth of Streptomyces sp. K07-0010, together with the known compounds NFAT-133, conglobatin, piericidin C series and dinactin. Structures of panowamycins were elucidated as new analogs of NFAT-133 by spectroscopic studies including various NMR experiments. Panowamycins A and B showed moderate antitrypanosomal activity, with IC50 values of 0.40 and 3.30 mu g ml(-1), respectively. The Journal of Antibiotics (2012) 65, 197-202; doi:10.1038/ja.2011.139; published online 25 January 2012