Natriuretic peptide receptor A is related to the expression of vascular endothelial growth factors A and C, and is associated with the invasion potential of tongue squamous cell carcinoma
Natriuretic peptide receptor A is related to the expression of vascular endothelial growth factors A and C, and is associated with the invasion potential of tongue squamous cell carcinoma
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DOI：
10.1016/j.ijom.2017.04.022
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发表时间：
2017-10-01
影响因子：
2.4
通讯作者：
Umeda, M.
中科院分区：
文献类型：
--
作者：
Nakao, Y.;Yamada, S.;Umeda, M.
钠尿肽受体A（NPRA）是钠尿肽受体之一。据报道，NPRA在各种肿瘤的致癌作用中发挥作用，以及在肾、心血管、内分泌和骨骼稳态中发挥功能作用。本研究旨在探讨舌鳞状细胞癌（TSCC）中NPRA的临床病理意义。NPRA在TSCC中的表达率（21/58，36.2%）高于正常口腔黏膜（0/10，0%）（P < 0.05）。根据侵袭模式，在较高级别的癌症中也更常见（1-2级vs.3 -4级，P < 0.01）。此外，N分类和NPRA表达之间存在关联的趋势（NO vs. N1-2，P = 0.06）。NPRA与VEGFA（P < 0.001）和VEGF-C（P < 0.001）的表达也存在显著相关性。NPRA高表达组的5年生存率为39.7%，而低表达组为97.0%，预后明显较差（P < 0.001）。多因素分析提示NPRA的过度表达也可能是独立的预后因素（P < 0.05）。总之，NPRA与VEGF表达水平、浸润和转移相关，可能是TSCC患者的预后因素。
Natriuretic peptide receptor A (NPRA) is one of the natriuretic peptide receptors. NPRA has been reported to play a role in the carcinogenesis of various tumours, as well as functional roles in renal, cardiovascular, endocrine, and skeletal homeostasis. The clinicopathological significance of NPRA in tongue squamous cell carcinoma (TSCC) was examined in this study. The overexpression of NPRA was more frequent in TSCC (21/58, 36.2%) than in the normal oral epithelium (0/10, 0%) (P < 0.05). It was also more frequently observed in cancers with higher grades according to the pattern of invasion (grades 1-2 vs. grades 3-4, P < 0.01). Additionally, there was a tendency towards an association between the N classification and NPRA expression (NO vs. N1-2, P = 0.06). Significant correlations were also observed between the expression of NPRA and that of VEGFA (P < 0.001) and VEGF-C (P < 0.001). The high-NPRA expression group had a significantly poorer prognosis, with a 5-year disease-specific survival rate of 39.7%, compared to 97.0% in the low-expression group (P < 0.001). Multivariate analysis suggested that the overexpression of NPRA may also be an independent prognostic factor (P < 0.05). In conclusion, NPRA is associated with VEGF expression levels, invasion, and metastasis, and may be a prognostic factor in TSCC patients.