Hearing in Drosophila.
Hearing in Drosophila.
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DOI：
10.1016/j.conb.2015.02.001
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发表时间：
2015-10
影响因子：
5.7
通讯作者：
Göpfert MC
中科院分区：
文献类型：
--
作者：
Albert JT;Göpfert MC
解剖声音转导与听觉信号处理。定义组织听纤毛和听神经元线路的转录因子。阐明听力障碍的环境和遗传原因。描述听觉感觉细胞的遗传库。对果蝇听觉系统的解剖揭示了果蝇和脊椎动物听觉之间的多重相似之处。最近的研究分析了果蝇大脑中听觉感觉细胞的运作和声音处理。神经元对声音的反应已经被表征，新的听觉神经元类别已经被定义；瞬时受体电位（TRP）通道与听觉转导有关，并且已经确定了听觉功能障碍的遗传和环境原因。这篇综述讨论了这些最近的进展对我们理解苍蝇的听力是如何发生的影响。
Dissecting sound transduction and auditory signal processing. Defining transcription factors that organize auditory cilia and auditory neuron wiring. Elucidating environmental and genetic causes of hearing impairments. Delineating the genetic repertoire of auditory sensory cells. The dissection of the Drosophila auditory system has revealed multiple parallels between fly and vertebrate hearing. Recent studies have analyzed the operation of auditory sensory cells and the processing of sound in the fly's brain. Neuronal responses to sound have been characterized, and novel classes of auditory neurons have been defined; transient receptor potential (TRP) channels were implicated in auditory transduction, and genetic and environmental causes of auditory dysfunctions have been identified. This review discusses the implications of these recent advances on our understanding of how hearing happens in the fly.