Diffusion tensor imaging fiber tractography for evaluating diffuse axonal injury
Diffusion tensor imaging fiber tractography for evaluating diffuse axonal injury
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DOI：
10.1080/02699050701311042
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发表时间：
2007-01-01
期刊：
影响因子：
1.9
通讯作者：
Izumi, Shin-Ichi
中科院分区：
文献类型：
--
作者：
Sugiyama, Ken;Kondo, Takeo;Izumi, Shin-Ichi
弥漫性轴突损伤 (DAI) 患者经常表现出慢性认知障碍。 DAI 的放射学识别有助于了解临床综合征并做出治疗决策。然而，CT 和常规 MRI 通常是正常的或显示与认知障碍关系不大的病变。最近，扩散张量成像（DTI）纤维束成像已被证明可用于检测各种类型的白质损伤。本研究的目的是评估使用 DTI 纤维束成像检测 DAI 患者病变的可行性，并将 DAI 病变与认知障碍相关联。我们调查了两名慢性 DAI 患者。两人都患有智力障碍，以及注意力和记忆障碍，限制了他们的日常生活活动。在这两名患者中，DTI 纤维束成像显示胼胝体和穹窿的白质纤维中断，而传统 MRI 未发现病变。涉及帕佩兹环路的穹窿中断可能与记忆障碍有关。因此，DTI纤维束成像可能是评估患有认知障碍的DAI患者的有用技术。
Patients with Diffuse axonal injury ( DAI) frequently exhibit cognitive disorders chronically. Radiologic recognition of DAI can help understand the clinical syndrome and to make treatment decisions. However, CT and conventional MRI are often normal or demonstrate lesions that are poorly related to the cognitive disorders. Recently, diffusion tensor imaging ( DTI) fiber tractography has been shown to be useful in detecting various types of white matter damage. The aim of this study was to evaluate the feasibility of using DTI fiber tractography to detect lesions in DAI patients, and to correlate the DAI lesions with the cognitive disorders. We investigated two patients with chronic DAI. Both had impaired intelligence, as well as attention and memory disorders that restricted their activities of daily living. In both patients, DTI fiber tractography revealed interruption of the white matter fibers in the corpus collosum and the fornix, while no lesions were found on conventional MRI. The interruption of the fornix which involves the circuit of Papez potentially correlates with the memory disorder. Therefore, DTI fiber tractography may be a useful technique for the evaluation of DAI patients with cognitive disorders.