Three major urinary metabolites of sinomenine in rats
Three major urinary metabolites of sinomenine in rats
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DOI：
10.1080/10286020500289444
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发表时间：
2007-01-01
影响因子：
1.7
通讯作者：
Yao, X.-S.
中科院分区：
文献类型：
--
作者：
Cheng, W.-M.;Qiu, F.;Yao, X.-S.
研究了青藤碱灌胃给药后大鼠尿中代谢产物的变化。获得了三种主要代谢产物，其特征为4-羟基-3，7，7-三甲氧基-17-甲基-（9 α，13 α，14 α）吗啡喃（1），7，8-二氢-4-羟基-3，7-二甲氧基-17-甲基-N-氧化物-（9 α，13 α，14 α）-吗啡烷-6-酮（2）和7，8-二异丙基-4-羟基-3，7-二甲氧基-（9 α，13 α，14 α）-吗啡烷-6-酮（3）。通过波谱分析鉴定了它们的结构，其中1和2为新化合物。
Urinary metabolites of sinomenine were investigated in rats after intragastric administration. Three major metabolites were obtained and characterised as 4-hydroxy-3,7,7-trimethoxy-17-methyl-(9 alpha,13 alpha,14 alpha)morphinan (1), 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-N-oxide-(9 alpha,13 alpha,14 alpha)-morphinan-6-one (2), and 7,8-didehydro-4-hydroxy-3,7-dimethoxy-(9 alpha,13 alpha,14 alpha)-morphinan-6-one (3). Their structures have been elucidated on the base of spectral analysis, among which 1 and 2 were new compounds.