Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma
Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma
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DOI：
10.1002/ijc.20067
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发表时间：
2004-06
影响因子：
6.4
通讯作者：
K. Yamashita;Yoichi Tanaka;K. Mimori;H. Inoue;M. Mori
中科院分区：
文献类型：
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作者：
K. Yamashita;Yoichi Tanaka;K. Mimori;H. Inoue;M. Mori
基质金属蛋白酶（MMP）是肿瘤进展的关键。在我们的研究中，我们评估了44例食管鳞状细胞癌（ESCC）中主要MMP家族（如MMP-3，MMP-9，MMP-11和MT 1-MMP）mRNA的预后意义，以及它们与尿激酶系统（uPA和uPAR）的关系。MT 1-MMP、MMP-11和MMP-2的表达密切相关，而MMP-9和uPAR的表达与前者呈负相关。没有MMP与临床病理因素相关;然而，与MT 1-MMP低表达的患者相比，MT 1-MMP高表达的患者可能显示更差的预后（p=0.01），以及MMP-11（p=0.02）。免疫组化显示两种MMP均在癌细胞中有明确表达。在高MT 1-MMP患者中，复发率（23/26：88.5%）比低MT 1-MMP患者（7/18：38.9%）更显著（p=0.0016）。在3年内死亡的20例病例中，所有15例MT 1-MMP高的病例均显示远处转移的初始复发，另外5例MT 1-MMP低的病例显示局部复发（p=0.000064）。这些结果可能表明，存在临床显著MMP相关表达的相关机制，其中，MT 1-MMP在ESCC进展中起着最关键的作用。© 2004 Wiley利斯公司
Matrix metalloproteinase (MMP) is critical for carcinoma progression. In our study, we evaluated the prognostic significance of the major MMP family such as MMP‐3, MMP‐9, MMP‐11 and MT1‐MMP at the mRNA in 44 esophageal squamous cell carcinoma (ESCC) that were previously characterized for MMP‐7, MMP‐1 and MMP‐2, and their relation to urokinase system (uPA and uPAR). MT1‐MMP, MMP‐11 and MMP‐2 expressions are closely associated with each other, while MMP‐9 and uPAR expressions are inversely associated with the former group. There is no MMP related to clinicopathological factors; however, patients with high MT1‐MMP could show worse prognosis, as compared to those with low MT1‐MMP expression (p=0.01), as well as MMP‐11 did (p=0.02). Both MMP showed clear expression of carcinoma cells by immunohistochemistry. In patients with high MT1‐MMP, recurrence was more prominent (23/26: 88.5%) than those with low MT1‐MMP (7/18: 38.9%) (p=0.0016). In the 20 cases who died within 3 years, all 15 cases with high MT1‐MMP showed initial recurrence of distant metastasis, and the other 5 cases with low MT1‐MMP showed locoregional recurrence (p=0.000064). These results could indicate that there is a relevant mechanism of associated expression of clinically significant MMP and that among them, MT1‐MMP plays the most critical role in ESCC progression. © 2004 Wiley‐Liss, Inc.