Bifurcation and chaos in a model of cardiac early afterdepolarizations.
Bifurcation and chaos in a model of cardiac early afterdepolarizations.
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心脏早期后除极模型中的分叉和混沌。
DOI：
10.1103/physrevlett.102.258103
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发表时间：
2009-06-26
影响因子：
8.6
通讯作者：
Qu, Zhilin
中科院分区：
文献类型：
--
作者：
Tran, Diana X.;Sato, Daisuke;Yochelis, Arik;Weiss, James N.;Garfinkel, Alan;Qu, Zhilin
可兴奋的细胞可以表现出复杂的振荡模式，例如尖峰和爆发。在心脏细胞中，病理性电压振荡，称为早期后除极（EAD），在疾病条件下已被广泛观察到，但其动力学机制仍不清楚。在这里，我们证明 EAD 是由 Hopf 和同宿分岔引起的。在周期起搏期间，随着刺激频率的降低，从无 EAD 到 EAD 的过渡处总是会出现混乱，这为实验中经常观察到的不规则 EAD 行为提供了新的解释。
Excitable cells can exhibit complex patterns of oscillations, such as spiking and bursting. In cardiac cells, pathological voltage oscillations, called early afterdepolarizations (EADs), have been widely observed under disease conditions, yet their dynamical mechanisms remain unknown. Here, we show that EADs are caused by Hopf and homoclinic bifurcations. During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a novel explanation for the irregular EAD behavior frequently observed in experiments.