Solvent oriented hobbies and the risk of systemic sclerosis.
Solvent oriented hobbies and the risk of systemic sclerosis.
复制标题
以溶剂为导向的爱好和系统性硬化症的风险。
作者：
P. Nietert;Susan E. Sutherland;Richard M. Silver;Janardan P Pandey;M. Dosemeci
目的
检查那些参与溶剂导向的嗜好（SOH）是否有更大的风险发展为系统性硬化症（SSc），如果协会是由抗Scl70抗体的存在修改。
方法
SSc患者和对照组从大学医院风湿病门诊招募。沿着血液样本获得了近期嗜好和职业史。为参与SOH创建了累积分数。Logistic回归用于计算调整性别、诊断时年龄和职业溶剂暴露后与SOH暴露相关的比值比，并检查SOH暴露与抗Scl 70存在之间的相关性。
结果
根据爱好和职业确定了178例病例（141名女性，37名男性）和200例对照（138名女性，62名男性）的溶剂暴露。SOH的总体参与与SSc无关。然而，抗Scl 70抗体检测阳性的SSc患者中高累积SOH暴露的几率是检测阴性患者的3倍（OR 2.9，95% CI 1.1，7.9），是对照组的2倍（OR 2.5，95% CI 1.1，5.9）。
结论
虽然SSc患者参与SOH的频率并不比对照组高，但与抗Scl 70检测阴性和对照组相比，SSc患者的高累积SOH暴露的几率更大。这些结果提供了进一步的证据表明，环境因素可能在发展中发挥作用的SSC。
OBJECTIVE
To examine whether those participating in solvent oriented hobbies (SOH) are at greater risk of developing systemic sclerosis (SSc), and if the association is modified by the presence of the anti-Scl70 antibody.
METHODS
Patients with SSc and controls were recruited from a university hospital rheumatology clinic. Recreational hobby and occupational histories were obtained along with blood samples. Cumulative scores were created for participation in SOH. Logistic regression was used to calculate odds ratios associated with SOH exposure after adjustment for sex, age at diagnosis, and occupational solvent exposure, and to examine the association between SOH exposure and the presence of anti-Scl70.
RESULTS
Solvent exposure based on hobbies and occupations was determined for 178 cases (141 women, 37 men) and 200 controls (138 women, 62 men). Overall participation in SOH was not associated with SSc. However, odds of high cumulative SOH exposure was 3 times greater in those patients with SSc testing positive for the anti-Scl70 antibody compared to patients testing negative (OR 2.9, 95% CI 1.1, 7.9), and twice as great as controls (OR 2.5, 95% CI 1.1, 5.9).
CONCLUSION
While patients with SSc did not participate more often in SOH than controls over all, odds of high cumulative SOH exposure was greater among patients with SSc testing positive for anti-Scl70 compared to those testing negative and compared to controls. These results provide further evidence that environmental agents may play a role in the development of Ssc.