Dynamics of stimulus-evoked spike timing correlations in the cat lateral geniculate nucleus
Dynamics of stimulus-evoked spike timing correlations in the cat lateral geniculate nucleus
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猫外侧膝状核中刺激诱发的尖峰计时相关性的动态
DOI：
10.1152/jn.01000.2009
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
PE. Maldonado and CM. Gray
中科院分区：
文献类型：
--
作者：
H. Ito;PE. Maldonado and CM. Gray
精确同步的神经元活动在哺乳动物的视觉通路中已被普遍观察到。外侧膝状体核（LGN）中的发放时序相关性在高γ频率范围内通常采取相位同步振荡的形式。为了研究振荡活动，同步性，和它们的时间依赖性之间的关系，我们记录了活动从多个单一的单位在猫LGN的刺激下，由固定的光点。自相关分析表明，约三分之一的细胞表现出振荡放电的平均频率为80 Hz。互相关分析表明，30%的单位对表现出显着的同步，61%的这些对包括同步振荡。互相关分析假设同步放电是固定的，并在整个刺激期间保持不变。我们通过应用单一事件分析（UEA）测试了这一假设。我们发现，UEA是更敏感的弱和短暂的同步比互相关分析，并检测到一个较高的发病率（49%的细胞对）的显着同步（单一事件）。在许多单元对中，单一事件的最佳特征在于1 ms的仓宽，表明神经同步具有高度的时间精度。我们还发现，大约一半的单位对显示非平稳的变化，同步，不能预测的调制的放电率。群体统计显示，LGN细胞之间的同步发生显着晚于视网膜传入和LGN细胞之间观察到的。在单独的四极上记录的单元对之间检测到的同步往往是更短暂的，并且比相邻单元之间观察到的同步具有更晚的发作。这些研究结果表明，刺激诱发的同步活动内的LGN往往是有节奏的，高度非平稳的，并调制的内源性过程，不紧密相关的放电率。
Precisely synchronized neuronal activity has been commonly observed in the mammalian visual pathway. Spike timing correlations in the lateral geniculate nucleus (LGN) often take the form of phase synchronized oscillations in the high gamma frequency range. To study the relations between oscillatory activity, synchrony, and their time-dependent properties, we recorded activity from multiple single units in the cat LGN under stimulation by stationary spots of light. Autocorrelation analysis showed that approximately one third of the cells exhibited oscillatory firing with a mean frequency ∼80 Hz. Cross-correlation analysis showed that 30% of unit pairs showed significant synchronization, and 61% of these pairs consisted of synchronous oscillations. Cross-correlation analysis assumes that synchronous firing is stationary and maintained throughout the period of stimulation. We tested this assumption by applying unitary events analysis (UEA). We found that UEA was more sensitive to weak and transient synchrony than cross-correlation analysis and detected a higher incidence (49% of cell pairs) of significant synchrony (unitary events). In many unit pairs, the unitary events were optimally characterized at a bin width of 1 ms, indicating that neural synchrony has a high degree of temporal precision. We also found that approximately one half of the unit pairs showed nonstationary changes in synchrony that could not be predicted by the modulation of firing rates. Population statistics showed that the onset of synchrony between LGN cells occurred significantly later than that observed between retinal afferents and LGN cells. The synchrony detected among unit pairs recorded on separate tetrodes tended to be more transient and have a later onset than that observed between adjacent units. These findings show that stimulus-evoked synchronous activity within the LGN is often rhythmic, highly nonstationary, and modulated by endogenous processes that are not tightly correlated with firing rate.