Inflammaging decreases adaptive and innate immune responses in mice and humans.
Inflammaging decreases adaptive and innate immune responses in mice and humans.
复制标题
DOI：
10.1007/s10522-015-9578-8
复制
发表时间：
2016-02
期刊：
影响因子：
4.5
通讯作者：
Blomberg BB
中科院分区：
文献类型：
--
作者：
Frasca D;Blomberg BB
先天性和适应性免疫系统都随着年龄的增长而下降，导致对传染病的易感性增加，对疫苗接种的反应降低。老年人的疾病比年轻人更严重，对发病率、残疾和死亡率等健康结果的影响更大。衰老的特征是轻度慢性炎症（称为“炎症”）增加，通过TNF-α、IL-6和CRP的循环水平以及病毒（如巨细胞病毒（CMV））的潜伏感染来测量。炎症受到了相当大的关注，因为它提出了免疫细胞变化与许多老年典型疾病和综合征之间的联系。本文就炎症反应的途径、炎症引起的免疫反应下调及机制等方面的研究进展进行综述。本综述中提出的老年人免疫反应的缺陷应有助于发现有效干预的途径，以促进健康老龄化。
Both the innate and adaptive immune systems decline with age, causing greater susceptibility to infectious diseases and reduced responses to vaccination. Diseases are more severe in elderly than in young individuals and have a greater impact on health outcomes such as morbidity, disability and mortality. Aging is characterized by increased low-grade chronic inflammation, called “inflammaging”, measured by circulating levels of TNF-α, IL-6 and CRP, as well as by latent infections with viruses such as cytomegalovirus (CMV). Inflammaging has received considerable attention because it proposes a link between changes in immune cells and a number of diseases and syndromes typical of old age. In this review we aim at summarizing the current knowledge on pathways contributing to inflammaging, on immune responses down-regulated by inflammation and mechanisms proposed. The defects in the immune response of elderly individuals presented in this review should help to discover avenues for effective intervention to promote healthy aging.