Lymphofollicular Hyperplastic Responses in Ectopic Locations: Trachoma as a Paradigm
Lymphofollicular Hyperplastic Responses in Ectopic Locations: Trachoma as a Paradigm
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异位部位的淋巴滤泡增生反应：以沙眼为范例
DOI：
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发表时间：
1971
期刊：
影响因子：
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通讯作者：
R. A. Prendergast
中科院分区：
文献类型：
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作者：
A. Silverstein;R. A. Prendergast
就像许多陈腐的谋杀之谜中无处不在的管家一样，有组织的淋巴组织的生殖中心长期以来一直被怀疑在抗原刺激的免疫反应之谜中发挥着核心作用。在这种情况下，许多调查人员的广泛侦查工作也产生了一个几乎令人信服的间接证据，以牵连到German中心，如果不是作为主犯之一，那么至少是一个重要的同谋。正如其名称所暗示的，生发中心长期以来被认为是一般淋巴细胞生成的过度活跃的焦点，最近它被认为是抗原定位和保留的中心（1，2），或者作为免疫记忆的所在地（3，4）。
Like the ubiquitous butler in many a trite murder mystery, the germinal center of organized lymphoid tissue has long been suspected of playing a central role in the mystery of the immune response to antigenic stimulus. In this situation also, extensive detective work by numerous investigators has produced an almost compelling body of circumstantial evidence to implicate the germinal center, if not as one of the principals, then at least as an important accomplice. As its name implies, the germinal center was long considered to be a hyperactive focus of general lymphopoiesis, and more recently it has been implicated as a center for antigen localization and retention (1,2) or alternatively as the seat of immunologic memory (3,4).