Will stem cells bring hope to pathological skin scar treatment?
Will stem cells bring hope to pathological skin scar treatment?
复制标题
干细胞会给病理性皮肤疤痕治疗带来希望吗？
DOI：
10.1016/j.jcyt.2016.05.008
复制
发表时间：
2016-08-01
期刊：
影响因子：
4.5
通讯作者：
Fu, Xiaobing
中科院分区：
文献类型：
--
作者：
Li, Qiankun;Zhang, Cuiping;Fu, Xiaobing
病理性皮肤疤痕，如瘢痕疙瘩，会在美学和心理上影响患者。对减少疤痕的追求和对患者满意度的日益认可导致了对疤痕治疗的持续探索。干细胞是一种很有前途的组织修复和再生来源。这些细胞的多潜能和分泌功能可能为病理性瘢痕提供可能的治疗方法，并已在最近的研究中进行了检测。本文分析了影响病理性皮肤瘢痕形成的因素，综述了近年来干细胞治疗病理性瘢痕的研究进展，并对其可能的作用机制进行了阐述。此外，在评估基于干细胞的病理性瘢痕治疗的潜在副作用时，还介绍了干细胞治疗的其他影响。因此，这篇综述可能会为干细胞治疗瘢痕提供有意义的临床指导。
Pathological skin scars, such as keloids, aesthetically and psychosocially affect patients. The quest for scar reduction and the increasing recognition of patient satisfaction has led to the continued exploration of scar treatment. Stem cells are a promising source for tissue repair and regeneration. The multi-potency and secretory functions of these cells could offer possible treatments for pathological scars and have been examined in recent studies. Here, we analyze the factors that influence the formation of pathological skin scars, summarize recent research on pathological scar treatment with stem cells and elaborate on the possible mechanisms of this treatment. Additionally, other effects of stem cell treatments are also presented while evaluating potential side effects of stem cell-based pathological scar treatments. Thus, this review may provide meaningful guidance in the clinic for scar treatments with stem cells.