Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/photodynamic/radiation synergistic cancer therapy
Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/photodynamic/radiation synergistic cancer therapy
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单根 W18O49 纳米线：用于计算机断层扫描成像和光热/光动力/辐射协同癌症治疗的多功能纳米平台
DOI：
10.1007/s12274-015-0858-z
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发表时间：
2015-11-01
期刊：
影响因子：
9.9
通讯作者：
Bu, Wenbo
中科院分区：
文献类型：
--
作者：
Qiu, Jianjian;Xiao, Qingfeng;Bu, Wenbo
联合疗法是一种有前途的癌症治疗策略，其通常基于利用具有多个组分的复杂纳米结构，所述多个组分用作光热能量转换器、光敏剂或用于光热疗法（PTT）、光动力疗法（PDT）或放射疗法（RT）的剂量增强剂。在这项研究中，钨氧化物纳米线（W18 O 49）的合成使用溶剂热法和检查作为一个多功能的治疗诊断纳米平台。体外和体内分析表明，这些纳米线可以诱导广泛的热和单线态氧介导的损伤下980 nm近红外（NIR）激光激发的癌细胞。它们还显示出作为辐射剂量增强剂的功能，其在放射治疗期间局部地和选择性地增强辐射能量沉积。与NIR诱导的PTT/PDT和RT单独相比，基于W18 O 49的协同三模式疗法根除了异种移植肿瘤，并且在9个月的随访内没有观察到复发。此外，钨元素的强X射线衰减能力（Z = 74，4.438 cm 2·g-1，100 KeV）使这些纳米线在基于X射线的成像中成为优异的造影剂，例如用于图像引导放射治疗的诊断计算机断层扫描（CT）和锥形束CT。毒性研究表明，一个月内对小鼠血液系统和主要器官的不良影响极小。总之，这些纳米线具有固有的图像引导和光疗和放疗的协同效应，在癌症治疗中显示出显着的潜力，值得进一步研究。
Combination therapy is a promising cancer treatment strategy that is usually based on the utilization of complicated nanostructures with multiple components functioning as photo-thermal energy transducers, photo-sensitizers, or dose intensifiers for photothermal therapy (PTT), photodynamic therapy (PDT), or radiation therapy (RT). In this study, ultrathin tungsten oxide nanowires (W18O49) were synthesized using a solvothermal approach and examined as a multifunctional theranostic nanoplatform. In vitro and in vivo analyses demonstrated that these nanowires could induce extensive heat- and singlet oxygen-mediated damage to cancer cells under 980 nm near infrared (NIR)-laser excitation. They were also shown to function as radiation dose intensifying agents that enhance irradiative energy deposition locally and selectively during radiation therapy. Compared to NIR-induced PTT/PDT and RT alone, W18O49-based synergistic tri-modal therapy eradicated xenograft tumors and no recurrence was observed within a 9-month follow up. Moreover, the strong X-ray attenuation ability of the tungsten element (Z = 74, 4.438 cm2·g–1, 100 KeV) qualified these nanowires as excellent contrast agents in X-ray-based imaging, such as diagnostic computed tomography (CT) and cone-beam CT for image-guided radiation therapy. Toxicity studies demonstrated minimal adverse effects on the hematologic system and major organs of mice within one month. In conclusion, these nanowires have shown significant potential for cancer therapy with inherent image guidance and synergistic effects from phototherapy and radiation therapy, which warrants further investigation.