The effects of dietary ferric iron and iron deprivation on the bacterial composition of the mouse intestine
The effects of dietary ferric iron and iron deprivation on the bacterial composition of the mouse intestine
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DOI：
10.1007/s002840010257
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发表时间：
2001-07-01
影响因子：
2.6
通讯作者：
Pennington, CB
中科院分区：
文献类型：
--
作者：
Tompkins, GR;O'Dell, NL;Pennington, CB
研究了膳食三价铁对小鼠肠道微生物群的影响，以促进良性乳酸菌（具有最低的铁需求），从而增强定植抗性潜力。三组八只小鼠接受了仅铁含量不同的饮食，为期12周。膳食缺铁导致包括乳酸菌在内的小肠细菌总数总体增加，但这些差异通常不显著（p > 0.05）。除大肠菌群外，所有检测的细菌群（厌氧菌、微需氧菌、乳酸杆菌和肠球菌）在缺铁小鼠的结肠中均显著升高（p < 0.05）。在充满铁和铁超载小鼠的结肠中的总厌氧菌的数量相对较低，这表明，以及在缺铁条件下促进细菌，提供三价铁抑制细菌，可能是通过氧化正常还原环境。
The influence of dietary ferric iron on the intestinal microbiota of mice was investigated with a view to promoting benign lactic acid bacteria (which have minimal iron requirements) in order to enhance colonization-resistance potential. Three groups of eight mice received a diet differing only in iron content, for a period of 12 weeks. Dietary iron deprivation resulted in overall increased small intestinal bacterial populations, including lactic acid bacteria, but these differences were generally not significant (p > 0.05). With the exception of coliforms, all examined bacterial groups (anaerobes, micro-aerophiles, lactobacilli, and enterococci) were significantly (p < 0.05) elevated in the colons of iron-deprived mice. The relatively low numbers of total anaerobes in the colons of iron-replete and iron-overloaded mice suggested that, as well as promotion of bacteria under iron-deprived condition, provision of ferric iron suppressed bacteria, probably by oxidation of normally reduced environments.