Time-Lapse Analysis Reveals Local Asymmetrical Changes in C-Looping Heart Tube
Time-Lapse Analysis Reveals Local Asymmetrical Changes in C-Looping Heart Tube
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DOI：
10.1002/dvdy.21662
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发表时间：
2008-12-01
影响因子：
2.5
通讯作者：
Tamura, Koji
中科院分区：
文献类型：
--
作者：
Kidokoro, Hinako;Okabe, Masataka;Tamura, Koji
心脏发育长期以来一直是左右不对称形态发生的模型系统，许多关键的偏侧性基因已被证明参与了不对称心脏循环的过程。我们建立了一个延时成像系统来观察鸡心脏发育过程中的C-循环过程，我们的观察表明，C-循环是一个非常复杂的过程，涉及几个局部形状的变化：该过程可分为吻、尾段右旋，吻部腹侧弯曲，顺时针旋转，尾部左侧部分扩大。进一步的实验操作揭示了这些形态变化和区域相互作用的事件的特点，我们建议，不对称扩大的尾部是在C-循环过程中的偏侧基因的目标之一。发展动力学237：3545-3556，2008年。(C)2008 Wiley-Liss，Inc.
Heart development has long served as a model system of left-right asymmetrical morphogenesis, and many key laterality genes have been shown to be involved in the process of asymmetrical heart looping. We established a time-lapse imaging system to observe the process of C-looping during chick heart development, and our observations showed that the C-looping is a very complicated process that involves several local changes in shape: the process can be divided into dextral rotation of the rostral and caudal segments with ventral bending in the rostral part and horizontal anti-clockwise rotation with enlargement of the left part in the caudal segment. Further experimental manipulations revealed characteristics of these morphological changes and regional interactions for the events, and we propose that asymmetrical enlargement of the caudal part is one of the targets of the laterality genes in the C-looping process. Developmental Dynamics 237:3545-3556, 2008. (C) 2008 Wiley-Liss, Inc.