Heroin craving and drug use in opioid-maintained volunteers: Effects of methadone dose variations
Heroin craving and drug use in opioid-maintained volunteers: Effects of methadone dose variations
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DOI：
10.1037//1064-1297.10.1.39
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发表时间：
2002-02-01
影响因子：
2.3
通讯作者：
Greenwald, MK
中科院分区：
文献类型：
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作者：
Greenwald, MK
最近的数据表明，阿片类药物激动剂和拮抗剂的挑战分别减少和增加了身体依赖个体对海洛因的渴望。这项研究调查了美沙酮剂量变化对接受应急资金的 IS 门诊患者的渴望和新药使用的影响。在第一阶段，志愿者在不同的测试中被告知美沙酮剂量会增加、减少或保持不变；戒毒紧急事件暂停 24 小时。仅当剂量减少与剂量减少指令相结合时，渴望显着增加，新的海洛因使用量略有增加（相对于维持剂量）。在第二阶段（戒毒），随着美沙酮剂量的减少，对海洛因的渴望和使用显着增加。因此，mu-受体激动剂作用的丧失会增加渴望和复发的风险。
Recent data indicate that opioid agonist and antagonist challenges decrease and increase (respectively) heroin craving in physically dependent individuals. This study investigated effects of methadone dose variations on craving and new drug use in IS outpatients who were given money contingencies. In Phase 1, volunteers were told in different test sessions that methadone dose would increase, decrease, or stay the same; drug-abstinence contingencies were suspended for 24 hr. Craving significantly increased and new heroin use marginally increased (relative to maintenance dose) only when a dose reduction was paired with a dose decrease instruction. In Phase 2 (detoxification), craving and heroin use significantly increased as methadone dose decreased. Thus, loss of mu-receptor agonist effect increased craving and risk of relapse.