DYNAMICS OF FEVER AND SERUM LEVELS OF TUMOR-NECROSIS-FACTOR ARE CLOSELY ASSOCIATED DURING CLINICAL PAROXYSMS IN PLASMODIUM-VIVAX MALARIA
DYNAMICS OF FEVER AND SERUM LEVELS OF TUMOR-NECROSIS-FACTOR ARE CLOSELY ASSOCIATED DURING CLINICAL PAROXYSMS IN PLASMODIUM-VIVAX MALARIA
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DOI：
10.1073/pnas.89.8.3200
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发表时间：
1992-04-15
影响因子：
11.1
通讯作者：
MENDIS, KN
中科院分区：
文献类型：
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作者：
KARUNAWEERA, ND;GRAU, GE;MENDIS, KN
阵发性是指在间日疟原虫感染中每48小时发生一次的伴有寒战和严寒的剧烈高烧发作。我们测定了感染间日疟原虫的非免疫性患者发作期血清肿瘤坏死因子(TNF)水平的变化。肿瘤坏死因子水平的变化与发作期体温的升降密切相关，但往往比发作期提前30-60分钟。这些观察结果表明，间日疟原虫暴发期间体温的上升和下降可能与感染期间引起的肿瘤坏死因子水平的周期性变化直接相关。间日疟原虫感染期间达到的最高肿瘤坏死因子水平远高于严重和致命的恶性疟原虫感染期间的水平，在恶性疟原虫感染中，肿瘤坏死因子被认为是导致该病严重表现的原因之一。
Paroxysms are sharp episodes of high fever accompanied by chills and rigors that occur periodically, once in every 48 hr in Plasmodium vivax infections. We have measured the changing levels of serum tumor necrosis factor (TNF) during paroxysms in non-immune patients infected with P. vivax malaria. The changes in TNF levels closely paralleled the rise and fall in temperature during the paroxysms but tended to precede them by 30-60 min. These observations suggest that the rise and fall in temperature during P. vivax paroxysm may be directly related to the periodic changes in TNF levels induced during these infections. The peak TNF levels reached during P. vivax infections were much higher than even those which have been recorded during severe and fatal P. falciparum infections in which TNF has been postulated to contribute to the severe manifestations of this disease.