Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains
Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains
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DOI：
10.1023/a:1020832327983
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发表时间：
2002-11-01
影响因子：
2.6
通讯作者：
Tordoff, MG
中科院分区：
文献类型：
--
作者：
Bachmanov, AA;Beauchamp, GK;Tordoff, MG
对来自28个近交系(129P3/J、A/J、AKR/J、BALB/cByJ、BUB/BNJ、C3H/HeJ、C57BL/6J、C57L/J、CAST/EI、CBA/J、CE/J、DBA/2J、FVB/NJ、I/LnJ、KK/HIJ、LP/J、NOD/LTJ、NZB/B1NJ、P/J、PL/J、RBF/DNJ、RF/J、RIIIS/J、SEA/J、SJL/J、SM/J、SPRET/EI和SWR/J)的雄性小鼠进行了氯化钠(75-450 mm)、KCI(30-300 mm)、CaCl(2)(3-100 mm)和NH(4)C1(10-300 mm)溶液采用双瓶偏好试验，以水为第二选择。对于每种矿物质，在溶液摄入量和偏好上都有很大范围的应变差异。根据遗传力估计，这种变异有很大的遗传成分。在大多数情况下，菌株的平均值是连续分布的；然而，也可以观察到具有偏离高或低摄入量或偏好的菌株。对不同矿物质的反应之间的关联仅是温和的，这表明钠、钾、钙和铵的消耗受到明显的遗传控制。这些结果为研究人员提供了宝贵的资源，他们希望确定与矿物质消耗和平衡调节有关的基因。
Male mice from 28 inbred strains (129P3/J, A/J, AKR/J, BALB/cByJ, BUB/BnJ, C3H/HeJ, C57BL/6J, C57L/J, CAST/Ei, CBA/J, CE/J, DBA/2J, FVB/NJ, I/LnJ, KK/HIJ, LP/J, NOD/LtJ, NZB/B1NJ, P/J, PL/J, RBF/DnJ, RF/J, RIIIS/J, SEA/GnJ, SJL/J, SM/J, SPRET/Ei, and SWR/J) were tested with NaCl (75-450 mM), KCI (30-300 mM), CaC1(2) (3-100 mM), and NH(4)C1 (10-300 mM) solutions using two-bottle preference tests with water as the second choice. For each mineral, there was a wide range of strain variation in solution intakes and preferences. This variation had a substantial genetic component as assessed using heritability estimates. In most cases, the strain means were continuously distributed; however, strains with deviating high or low intakes or preferences were also observed. The associations among the responses to different minerals were only modest, suggesting distinct genetic controls of sodium, potassium, calcium, and ammonium consumption. These results provide a valuable resource for investigators who wish to identify genes involved in the regulation of mineral consumption and balance.