AN APPROACH FOR TIME-DEPENDENT BONE MODELING AND REMODELING - THEORETICAL DEVELOPMENT
AN APPROACH FOR TIME-DEPENDENT BONE MODELING AND REMODELING - THEORETICAL DEVELOPMENT
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DOI：
10.1002/jor.1100080506
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发表时间：
1990-09-01
影响因子：
2.8
通讯作者：
CARTER, DR
中科院分区：
文献类型：
--
作者：
BEAUPRE, GS;ORR, TE;CARTER, DR
一个时间依赖性的方法来模拟骨建模和重塑，以响应每日的负荷历史。我们假设，基因型，全身代谢条件，和局部组织的相互作用建立适当的骨组织的维护局部组织的机械刺激（吸引状态）的水平。骨表面上的净日附着率或吸收率由实际刺激和组织吸引状态之间的差异决定，并且可以由其他生物因素调节。在计算局部骨表观密度的净变化时，该技术考虑了可用于成骨细胞和成骨细胞活性的骨表面积。骨内膜、骨膜、哈弗氏体和松质骨的建模和重塑从而以一致的、统一的方式进行处理。
A time-dependent approach for emulating bone modeling and remodeling in response to the daily loading history is presented. We postulate that genotype, systemic metabolic conditions, and local tissue interactions establish the level of local tissue mechanical stimulation (attractor state) appropriate for the maintenance of bone tissue. The net daily rate of apposition or resorption on a bone surface is determined by the difference between the actual stimulus and the tissue attractor state and can be modulated by other biologic factors. In calculating the net change in local bone apparent density, the technique takes into account the bone surface area available for osteoblastic and osteoclastic activity. Endosteal, periosteal, haversian, and cancellous bone modeling and remodeling are thereby treated in a consistent, unified fashion.