FlyRNAi:: the Drosophila RNAi screening center database
FlyRNAi:: the Drosophila RNAi screening center database
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DOI：
10.1093/nar/gkj114
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发表时间：
2006-01-01
影响因子：
14.9
通讯作者：
Mathey-Prevot, Bernard
中科院分区：
文献类型：
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作者：
Flockhart, Ian;Booker, Matthew;Mathey-Prevot, Bernard
RNA干扰（RNAi）已成为果蝇基因筛选的有力工具。在果蝇RNAi筛选中心（DRSC），我们正在使用一个包含21000多个双链RNA的文库，靶向果蝇中已知和预测的基因。该文库可供希望进行全基因组RNAi筛选的访问科学家使用。这些筛选产生的数据以灵活的格式收集在DRSC数据库（http：//flyRNAi.org/cgi-bin/RNAi_screens.pl）中，以方便科学家和存档数据。该数据库的长期目标是为果蝇中尽可能多的未表征基因提供注释。通过高度可配置的界面，公众可以获得来自已发布屏幕的数据，该界面允许对数据进行详细检查，并提供对许多其他数据库和生物信息学工具的访问。
RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21 000 double-stranded RNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens are collected in the DRSC database (http://flyRNAi.org/cgi-bin/RNAi_screens.pl) in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools.