THE BASAL NUCLEUS OF MEYNERT REVISED - THE NERVE-CELL NUMBER DECREASES WITH AGE
THE BASAL NUCLEUS OF MEYNERT REVISED - THE NERVE-CELL NUMBER DECREASES WITH AGE
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DOI：
10.1016/0167-4943(89)90066-6
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发表时间：
1989-01-01
影响因子：
4
通讯作者：
CERVOSNAVARRO, J
中科院分区：
文献类型：
--
作者：
LOWESHUMMEL, P;GERTZ, HJ;CERVOSNAVARRO, J
在大脑的某些区域存在与年龄相关的神经细胞丢失，而其他大脑区域则随着年龄的增长保持稳定。Meynert基底核(NBM)被认为是大脑皮层胆碱能神经支配的来源，其神经元的丧失似乎伴随着认知障碍。因此，NBM的正常年龄动力学是相当重要的。对16个人的大脑进行了尸检，年龄从怀孕35周到90岁不等。包含整个NBM的块被切成20-.MU。厚连续切片，每隔25个切片行甲酚紫染色和形态计量学分析。右侧大脑半球的神经细胞计数略高，但明显较高。第9个十年的神经元总数比新生儿低23%。这一下降在统计上是显著的。我们假设有一个神经细胞的阈值数量，低于这个阈值数量认知障碍的可能性很高。
There is an age-dependent nerve cell loss in some areas of the brain, while other brain regions are stable with aging. The nucleus basalis of Meynert (NbM) is believed to be the source of cholinergic innervation of the cerebral cortex, and loss of its neurons seems to be followed by cognitive deficits. The normal age kinetics of the NbM are, therefore, of considerable importance. Sixteen autoptic human brains were examined, ages ranging from the 35th week of gestation to 90 years of age. Blocks containing the NbM in its entirety were cut into 20-.mu. thick serial sections; every 25th section was cresyl-violet stained and underwent morphometric analysis. Nerve cell counts were slightly but significantly higher in the right hemisphere. The total number of neurons in the 9th decade was 23% below that in newborns. This decrease was statistically significant. We hypothesize that there is a threshold number of nerve cells below which cognitive failure is highly probable.