OGTT results in obese adolescents with normal HOMA-IR values
OGTT results in obese adolescents with normal HOMA-IR values
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DOI：
10.1515/jpem-2012-0206
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
N. Şahin;S. Kınık;M. Tekindal
中科院分区：
文献类型：
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作者：
N. Şahin;S. Kınık;M. Tekindal
摘要目的：目的探讨空腹胰岛素和胰岛素抵抗稳态模型（HOMA-IR）正常的肥胖青少年的OGTT胰岛素抵抗（IR）。受试者：共97名肥胖青少年，OGTT中HOMA-IR值为2083.5 pmol/L（300 μU/mL）。IR危险因素包括糖尿病家族史、黑棘皮病（AN）和肝脂肪变性。结果：61例（62.9%）患者出现IR。IR组的AN发生率显著更高（p=0.0001）。随着危险因素数量的增加，IR的频率也增加（p=0.01）。结论：对于HOMA-IR正常的肥胖青少年，如果存在IR的危险因素，我们建议进行OGTT。
Abstract Objective: To investigate insulin resistance (IR) with OGTT in obese adolescents who have normal fasting insulin and homeostasis model assessment for insulin resistance (HOMA-IR). Subjects: A total of 97 obese adolescents who had values of HOMA-IR 2083.5 pmol/L (300 μU/mL) in OGTT. IR risk factors were defined as family history of diabetes mellitus, acanthosis nigricans (AN), and hepatic steatosis. Results: IR was detected in 61 (62.9%) patients. The IR group had significantly more frequent AN (p=0.0001). As the number of risk factors increased, the frequency of IR also increased (p=0.01). Conclusion: We advise to perform OGTT in obese adolescents with normal HOMA-IR, if they have risk factors for IR.