Factors related to exercise capacity in asymptomatic middle-aged type 2 diabetic patients
Factors related to exercise capacity in asymptomatic middle-aged type 2 diabetic patients
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DOI：
10.1016/j.diabres.2004.06.005
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发表时间：
2005-02-01
影响因子：
5.1
通讯作者：
Tugrul, A
中科院分区：
文献类型：
--
作者：
Ugur-Altun, B;Altun, A;Tugrul, A
目的：我们的目的是观察连续10例无症状中年2型糖尿病患者的运动能力和代谢变量之间的关系，作为未诊断冠心病的潜在标志物。方法：90例患者（49 6岁）纳入研究。所有患者均采用布鲁斯方案进行平板运动试验。根据实现的EC，将患者分为三组;组I（n，24）8 >代谢当量（MET）大于或等于5，组II（n，54）11 > MET> 8和组III（n，12）MET> 11。结果如下：I组患者中女性和有冠心病家族史的可能性高于III组（分别为P = 0.015，P = 0.009）。与111组相比，I组患者的空腹胰岛素和纤维蛋白原水平较高（分别为P = 0.049和P = 0.01）。胰岛素抵抗的稳态模型评估（HOMA-IR）指数（P = 0.03）也高于组III。运动能力与年龄（r =-0.204，P = 0.048）、空腹胰岛素（r =-0.209，P = 0.048）、HOMA-IR（r =-0.204，P = 0.048）、纤维蛋白原（r =-0.301，P = 0.007）呈显著负相关。结论：在无症状中年2型糖尿病患者中，运动能力降低与HOMA-IR指数评估的胰岛素抵抗增加相关。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Aim: We aimed to look at the relationship between exercise capacity and metabolic variables in unselected consecutive asymptomatic middle-aged type 2 diabetic patients as a potential marker for undiagnosed coronary heart disease. Method: Ninety patients (49 6 years) were included in the study. All patients performed a treadmill exercise test using the Bruce protocol. According to achieved EC, patients were separated into three groups; Group I (n, 24) 8 > metabolic equivalents (METs) greater than or equal to 5, Group II (n, 54) 11 > METs > 8 and Group III (n, 12) METs > 11. Results: Patients in group I are more likely to be of female gender and to have a family history of coronary heart disease (CHD) than in group III (P = 0.015, P = 0.009, respectively). When compared to group 111, patients in group I had higher fasting insulin and fibrinogen levels (P = 0.049 and P = 0.01, respectively). Homeostasis model assessment for insulin resistance (HOMA-IR) index (P = 0.03) was also higher in group I than in group III. We found a significant negative correlation between achieved exercise capacity and age (r = -0.204, P = 0.048), fasting insulin (r = -0.209, P = 0.048), HOMA-IR (r = -0.204, P = 0.048) as well as fibrinogen (r = -0.301, P = 0.007). Conclusion: Reduced exercise capacity was associated with increased insulin resistance as assessed by HOMA-IR index in asymptornatic middle-aged type 2 diabetic patients.(C) 2004 Elsevier Ireland Ltd. All rights reserved.