Cell adhesion receptors in mechanotransduction
Cell adhesion receptors in mechanotransduction
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DOI：
10.1016/j.ceb.2008.05.005
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发表时间：
2008-10-01
影响因子：
7.5
通讯作者：
DeSimone, Douglas W.
中科院分区：
文献类型：
--
作者：
Schwartz, Martin A.;DeSimone, Douglas W.
整合素和钙粘蛋白是三功能的：它们结合其他细胞上或细胞外基质中的配体，连接到细胞内的细胞骨架，并调节细胞内信号传导途径。因此，这些粘附受体传递机械应力，并被很好地定位以介导机械转导。培养细胞的研究表明，整合素和钙粘蛋白介导的粘附本质上是机械敏感的。对机械刺激的反应中的粘连的加强可能是机械转导的中心机制。对发育中的生物体的研究表明，这些机制有助于组织水平对张力和压缩的反应，从而将形态发生运动与细胞命运决定联系起来。
Integrins and cadherins are tri-functional: they bind ligands on other cells or in the extracellular matrix, connect to the cytoskeleton inside the cell, and regulate intracellular signaling pathways. These adhesion receptors therefore transmit mechanical stresses and are well positioned to mediate mechanotransduction. Studies of cultured cells have shown that both integrin- and cadherin-mediated adhesion are intrinsically mechanosensitive. Strengthening of adhesions in response to mechanical stimulation may be a central mechanism for mechanotransduction. Studies of developing organisms suggest that these mechanisms contribute to tissue level responses to tension and compression, thereby linking morphogenetic movements to cell fate decisions.