Reduced reward-related probability learning in schizophrenia patients.
Reduced reward-related probability learning in schizophrenia patients.
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DOI：
10.2147/ndt.s26243
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发表时间：
2012
影响因子：
3.2
通讯作者：
Gonul AS
中科院分区：
文献类型：
--
作者：
Yılmaz A;Simsek F;Gonul AS
虽然已知精神分裂症患者在强化学习方面表现出明显的损伤，但这种损伤的细节尚不清楚。本研究的目的是验证精神分裂症患者的奖励相关概率学习发生改变的假设。25名临床稳定的精神分裂症患者和25名年龄和性别匹配的对照组参加了这项研究。我们使用了一个简单的赌博范例，其中五种不同的线索与不同的奖励概率（50%，67%和100%）相关联。参与者被要求对每个线索的奖励概率做出最好的猜测。与对照组相比，在奖励相关反馈的基础上，患者在学习附带事件上有显著的损害。相关分析显示，患者的损害程度与阳性和阴性症状量表测量的阴性症状严重程度部分相关，但与抗精神病药剂量无关。综上所述，本研究表明精神分裂症患者奖励性学习功能受损，且与药物状态无关。
Although it is known that individuals with schizophrenia demonstrate marked impairment in reinforcement learning, the details of this impairment are not known. The aim of this study was to test the hypothesis that reward-related probability learning is altered in schizophrenia patients. Twenty-five clinically stable schizophrenia patients and 25 age- and gender-matched controls participated in the study. A simple gambling paradigm was used in which five different cues were associated with different reward probabilities (50%, 67%, and 100%). Participants were asked to make their best guess about the reward probability of each cue. Compared with controls, patients had significant impairment in learning contingencies on the basis of reward-related feedback. The correlation analyses revealed that the impairment of patients partially correlated with the severity of negative symptoms as measured on the Positive and Negative Syndrome Scale but that it was not related to antipsychotic dose. In conclusion, the present study showed that the schizophrenia patients had impaired reward-based learning and that this was independent from their medication status.