Antineoplastic agents.: 551.: Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea
Antineoplastic agents.: 551.: Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea
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DOI：
10.1021/np058075
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发表时间：
2006-03-01
影响因子：
5.1
通讯作者：
Cragg, GM
中科院分区：
文献类型：
--
作者：
Pettit, GR;Numata, A;Cragg, GM
生物测定引导（P388淋巴细胞白血病细胞系）分离从羊蹄甲的叶、茎和豆荚制备的提取物，以及平行地，其根，导致分离四种新的二苯并[B，f]氧杂环庚三烯（2a，3-5），命名为羊蹄甲素1-4，以及已知的和相关的pacharin（1）作为癌细胞生长抑制剂。氧杂环庚三烯衍生物在自然界中的存在是相当罕见的。发现紫荆花素1-4对人癌细胞系的微型板显示出显著的生长抑制，并且还发现紫荆花素1（2a）抑制P388癌细胞系。这些新的癌细胞生长抑制剂的结构是通过光谱技术建立的，包括HRMS和2D NMR。
Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel, its roots, led to the isolation of four new dibenz[b,f]oxepins (2a, 3-5) named bauhiniastatins 1-4, as well as the known and related pacharin (1) as cancer cell growth inhibitors. The occurrence of oxepin derivatives in nature is quite rare. Bauhiniastatins 1-4 were found to exhibit significant growth inhibition against a minipanel of human cancer cell lines, and bauhiniastatin 1 (2a) was also found to inhibit the P388 cancer cell line. Structures for these new cancer cell growth inhibitors were established by spectroscopic techniques that included HRMS and 2D NMR.