Formulation of Poloxamers for Drug Delivery.
Formulation of Poloxamers for Drug Delivery.
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DOI：
10.3390/jfb9010011
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发表时间：
2018-01-18
影响因子：
4.8
通讯作者：
Alexandridis P
中科院分区：
文献类型：
--
作者：
Bodratti AM;Alexandridis P
泊洛沙姆，也称为Pluronics®，是聚（环氧乙烷）（PEO）和聚（环氧丙烷）（PPO）的嵌段共聚物，其具有两亲特性和由此产生的有用的缔合和吸附性质。泊洛沙姆可用于许多需要化合物增溶或稳定化的应用中，并且还具有显著的生理特性，包括低毒性。因此，泊洛沙姆很好地用作药物的赋形剂。纳米医学目前面临的挑战围绕着在整个身体中运输通常不溶于水的药物，然后进行靶向递送。药物递送系统的明智设计导致改善的生物利用度、患者依从性和治疗结果。富相行为（胶束、水凝胶、溶致液晶等）泊洛沙姆的特性使其适合多种类型的加工和各种产品形式。在这篇综述中，我们首先介绍了泊洛沙姆的一般溶液行为，重点是它们的自组装特性。其次是讨论如何利用泊洛沙姆的自组装特性来封装药物，使用一系列的处理技术，包括直接增溶，溶剂置换法，乳化和制备动力学冷冻的纳米颗粒。最后，我们总结和展望。
Poloxamers, also known as Pluronics®, are block copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), which have an amphiphilic character and useful association and adsorption properties emanating from this. Poloxamers find use in many applications that require solubilization or stabilization of compounds and also have notable physiological properties, including low toxicity. Accordingly, poloxamers serve well as excipients for pharmaceuticals. Current challenges facing nanomedicine revolve around the transport of typically water-insoluble drugs throughout the body, followed by targeted delivery. Judicious design of drug delivery systems leads to improved bioavailability, patient compliance and therapeutic outcomes. The rich phase behavior (micelles, hydrogels, lyotropic liquid crystals, etc.) of poloxamers makes them amenable to multiple types of processing and various product forms. In this review, we first present the general solution behavior of poloxamers, focusing on their self-assembly properties. This is followed by a discussion of how the self-assembly properties of poloxamers can be leveraged to encapsulate drugs using an array of processing techniques including direct solubilization, solvent displacement methods, emulsification and preparation of kinetically-frozen nanoparticles. Finally, we conclude with a summary and perspective.
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影响因子：
3.9
作者：
Alexandridis, P;Olsson, U;Lindman, B
通讯作者：
Lindman, B
DOI：
10.1016/j.msec.2016.05.088
发表时间：
2016-11-01
影响因子：
7.9
作者：
Akkari, Alessandra C. S.;Boava Papini, Juliana Z.;de Araujo, Daniele R.
通讯作者：
de Araujo, Daniele R.
影响因子：
3.9
作者：
ALEXANDRIDIS, P;ATHANASSIOU, V;HATTON, TA
通讯作者：
HATTON, TA
影响因子：
--
作者：
Alexandridis, P;Olsson, U;Lindman, B
通讯作者：
Lindman, B
影响因子：
3.9
作者：
Alexandridis, P;Zhou, DL;Khan, A
通讯作者：
Khan, A