A miniaturized chronic microelectrode drive for awake behaving head restrained mice and rats
A miniaturized chronic microelectrode drive for awake behaving head restrained mice and rats
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DOI：
10.1016/j.jneumeth.2009.12.015
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发表时间：
2010-03-15
影响因子：
3
通讯作者：
Schwarz, Cornelius
中科院分区：
文献类型：
--
作者：
Haiss, Florent;Butovas, Sergejus;Schwarz, Cornelius
目前的工作介绍了一种电极微驱动系统，该系统足够小，可以放置在头部固定小鼠的两个不同的大脑区域中。为了满足小鼠体型和头柱的额外存在所带来的空间限制，组件的尺寸和重量被最小化。在当前版本中，单个微驱动器移动四个 Reitboeck 型电极的阵列。我们报告了使用一两个微驱动器成功植入大鼠和小鼠的情况。在个体小鼠/大鼠中使用其中的两个设备，证明了来自前额叶、运动、体感皮层和海马体的并行单单元和多单元以及局部场电位的记录。该系统可以使用大多数神经生理学实验室中现有的机械和设备轻松构建。 (C) 2010 Elsevier B.V. 保留所有权利。
The present work introduces an electrode microdrive system small enough to be placed into two distinct brain areas in head-fixed mice. To meet the space constraint imposed by the size of mice and the additional presence of a head post, the size and weight of the components were minimized. In the current version, an individual microdrive moves an array of four Reitboeck type electrodes. We report about successful implantation in rats and mice using one or two microdrives. Using two of these devices in individual mice/rats, the recording of parallel single and multi-unit as well as local field potential from prefrontal, motor, somatosensory cortex and hippocampus is demonstrated. The system can be easily constructed with machinery and equipment present in most neurophysiology labs. (C) 2010 Elsevier B.V. All rights reserved.