Genomicus: a database and a browser to study gene synteny in modern and ancestral genomes
Genomicus: a database and a browser to study gene synteny in modern and ancestral genomes
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DOI：
10.1093/bioinformatics/btq079
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发表时间：
2010-04-15
期刊：
影响因子：
5.8
通讯作者：
Roest Crollius, Hugues
中科院分区：
文献类型：
--
作者：
Muffato, Matthieu;Louis, Alexandra;Roest Crollius, Hugues
比较基因组学仍然是研究基因组织进化的关键策略，公共资源库中可用的全基因组序列的数量不断增加，加强了这一首要地位。尽管有这种增长，但可用于可视化和比较基因组并推断进化事件的生物信息学工具仍然局限于一次两到三个基因组，从而限制了可以研究的问题的广度和性质。在这里，我们介绍Genomicus，一个新的同步浏览器，可以在广泛的系统发生学观点中表示和比较无限数量的基因组。此外，Genomicus还包括重建的祖先基因组织，从而极大地方便了数据的解释。
Comparative genomics remains a pivotal strategy to study the evolution of gene organization, and this primacy is reinforced by the growing number of full genome sequences available in public repositories. Despite this growth, bioinformatic tools available to visualize and compare genomes and to infer evolutionary events remain restricted to two or three genomes at a time, thus limiting the breadth and the nature of the question that can be investigated. Here we present Genomicus, a new synteny browser that can represent and compare unlimited numbers of genomes in a broad phylogenetic view. In addition, Genomicus includes reconstructed ancestral gene organization, thus greatly facilitating the interpretation of the data.