The discovery and development of cisplatin
The discovery and development of cisplatin
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DOI：
10.1021/ed083p728
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发表时间：
2006-05-01
影响因子：
3
通讯作者：
Hambley, TW
中科院分区：
文献类型：
--
作者：
Alderden, RA;Hall, MD;Hambley, TW
顺铂是目前世界上应用最广泛的抗癌药物之一。围绕其抗癌活性的发现，随后引入临床，并继续研究铂化合物的不太可能的事件是本次审查的主题。顺铂和相关的铂化合物仍然是广泛研究的焦点。已经开发了合成这些化合物的可靠方法，并且已经确定它们通过与DNA相互作用而发挥其抗癌活性。继续寻找铂类药物以改善顺铂的临床性能。一些已经进入临床试验，但由于各种原因被放弃。然而，新化合物的初步结果特别有希望。
Cisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its anticancer activity, subsequent introduction into the clinic, and the continuing research into platinum compounds is the subject of this review. Cisplatin and related platinum compounds remain the focus of extensive research. Reliable methods for the synthesis of such compounds have been developed and it has been established that they exert their anticancer activity through interaction with DNA. The search continues for a platinum drug to improve upon the clinical performance of cisplatin. Several have entered clinical trials but have been abandoned for a variety of reasons. However, preliminary results on novel compounds have been particularly promising.