Immunogenic Apoptotic Cell Death and Anticancer Immunity
Immunogenic Apoptotic Cell Death and Anticancer Immunity
复制标题
DOI：
10.1007/978-3-319-39406-0_6
复制
发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Krysko, Dmitri V.
中科院分区：
文献类型：
--
作者：
Vandenabeele, Peter;Vandecasteele, Katrien;Krysko, Dmitri V.
多年来，人们一直认为吞噬细胞快速清除的凋亡细胞不会引发免疫反应，而是具有抗炎特性。然而，越来越多的实验数据表明，某些抗癌疗法可以诱导与损伤相关分子模式（DAMP）的发射相关的免疫原性形式的细胞凋亡，其作为佐剂激活宿主抗肿瘤免疫应答。在本文中，我们将首先讨论最近的进展和危险信号通路参与DAMPs的排放，包括钙网蛋白，ATP和HMGB1的意义。我们还将强调，特定信号通路的开启取决于免疫原性细胞死亡刺激。此外，我们解决了ER应激在危险信号中的作用，以及与ER应激如何触发有关的免疫原性细胞死亡诱导物的分类。在最后一部分，我们讨论了放射治疗诱导的免疫原性细胞凋亡的作用及其免疫原性与分次剂量和伴随化疗的关系。
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies can induce an immunogenic form of apoptosis associated with the emission of damage-associated molecular patterns (DAMPs), which function as adjuvants to activate host antitumor immune responses. In this review, we will first discuss recent advances and the significance of danger signaling pathways involved in the emission of DAMPs, including calreticulin, ATP, and HMGB1. We will also emphasize that switching on a particular signaling pathway depends on the immunogenic cell death stimulus. Further, we address the role of ER stress in danger signaling and the classification of immunogenic cell death inducers in relation to how ER stress is triggered. In the final part, we discuss the role of radiotherapy-induced immunogenic apoptosis and the relationship of its immunogenicity to the fraction dose and concomitant chemotherapy.