Alterations in the Coagulation and Fibrinolysis System in Pregnancy Labour and Puerperium, with Special Reference to a Possible Transitory State of Intravascular Coagulation during Labour
Alterations in the Coagulation and Fibrinolysis System in Pregnancy Labour and Puerperium, with Special Reference to a Possible Transitory State of Intravascular Coagulation during Labour
复制标题
妊娠期和产褥期凝血和纤溶系统的变化，特别是分娩时可能存在的暂时性血管内凝血状态
DOI：
10.1055/s-0038-1648672
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发表时间：
1978
影响因子：
6.7
通讯作者：
A. Estellés
中科院分区：
文献类型：
--
作者：
J. Gilabert;Justo Aznar;Parrilla Jj;E. Réganon;V. Vila;A. Estellés
在妊娠、分娩和产褥期对259名妇女进行了各种止血试验。在第1、第2和第3孕期、扩张期、排出期、胎盘排出期和产后立即分娩期以及产褥期前5天的每一天进行测定。经证实，在妊娠期间，纤维蛋白原降解产物（FDP）水平升高，硫酸鱼精蛋白和乙醇试验阳性数量成比例增加。硫酸鱼精蛋白和乙醇试验阳性的比例在胎盘排出时达到最大值，这与聚丙烯酰胺凝胶电泳和柱色谱法检测到的比纤维蛋白原重的可溶性复合物的存在相一致。所有这些都表明，在分娩过程中会产生短暂的血管内凝血，在出生时达到最大值，在产褥期的头几天趋于正常。
Summary Various tests of hemostasis were carried out during pregnancy, labour and the puerperium in a group of 259 women. Determinations were carried out in the 1st, 2nd and 3rd trimesters, in the period of dilatation, the expulsion period, the period of expulsion of the placenta and the immediate postpartum period of labour and on each of the first 5 days of the puerperium. It was confirmed that during pregnancy there is an elevation of the fibrinogen degradation producs (FDP) levels with a proportional increase in the numbers of positive protamine sulfate and ethanol tests. The proportion of positive protamine sulfate and ethanol tests reaches a maximum in the expulsion of the placenta coinciding with the presence of soluble complexes heavier than fibrinogen as detected by polyacrylamide gel electrophoresis and by column chromatography. All this indicates that there is a transitory intravascular coagulation produced during labour reaching its maximum at the time of birth and tending to become normalized in the first few days of the puerperium.