Decreased Human Leukocyte Antigen-G Expression by miR-133a Contributes to Impairment of Proinvasion and Proangiogenesis Functions of Decidual NK Cells.
Decreased Human Leukocyte Antigen-G Expression by miR-133a Contributes to Impairment of Proinvasion and Proangiogenesis Functions of Decidual NK Cells.
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mir-133a 降低人类白细胞抗原 G 表达导致蜕膜 NK 细胞的前侵袭和促血管生成功能受损
DOI：
10.3389/fimmu.2017.00741
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发表时间：
2017
影响因子：
7.3
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Guo W;Fang L;Li B;Xiao X;Chen S;Wang J;Yang F;Chen L;Wang X
人类白细胞抗原（HLA）-G在赋予胎儿-母体耐受性和确保成功妊娠中起着至关重要的作用。CD 56 bright自然杀伤（NK）细胞在妊娠期间大量积聚在母体蜕膜中，并与胎儿滋养层直接接触。越来越多的证据表明，蜕膜NK细胞（dNK细胞）对妊娠至关重要。然而，dNK细胞的调节大多是未知的。本研究为反复自然流产患者dNK细胞分泌功能受损，导致其促侵袭和促血管生成功能受损提供了证据。在HTR-8/SVneo中转染miR-133 a模拟物诱导的HLA-G表达降低影响dNK细胞的分泌功能。因此，我们的数据显示，dNK细胞的功能可以通过HLA-G表达的降低而被抑制，并提示了复发性流产的可能机制。
Human leukocyte antigen (HLA)-G plays a crucial role in conferring fetal–maternal tolerance and ensuring a successful pregnancy. CD56bright natural killer (NK) cells accumulate at the maternal decidua in large numbers during pregnancy and are found in direct contact with fetal trophoblasts. There are increasing evidences that decidual NK (dNK) cells are crucial for pregnancy. However, the regulation of dNK cells is mostly unknown. Here, we provide evidences that the secretion function of dNK cells in recurrent spontaneous abortion was impaired, which led to the impairment of the proinvasion and proangiogenesis functions of dNK cells. Decreased HLA-G expression induced by the transfection of miR-133a mimics in HTR-8/SVneo affected the secretory functions of dNK cells. Thus, our data revealed that the functions of dNK cells could be suppressed by the decreased expression of HLA-G and suggest a possible mechanism of recurrent miscarriage.