Microglia enable cross-modal plasticity by removing inhibitory synapses
Microglia enable cross-modal plasticity by removing inhibitory synapses
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DOI：
10.1016/j.celrep.2023.112383
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发表时间：
2023-05-30
期刊：
影响因子：
8.8
通讯作者：
Wake，Hiroaki
中科院分区：
文献类型：
--
作者：
Hashimoto，Akari;Kawamura，Nanami;Wake，Hiroaki
跨模式可塑性是指重新利用与被剥夺的感觉输入相关的大脑区域，以提高其他感觉模式的能力。跨模式可塑性的功能机制可以表明大脑如何从各种形式的损伤中恢复以及不同的感觉模式如何整合。在这里，我们证明小胶质细胞介导的局部电路突触的重新布线对于视觉剥夺（单眼剥夺[MD]）引起的跨模式可塑性至关重要。 MD 缓解了体感皮层和次级侧视觉皮层 (V2L) 之间功能连接的通常抑制。这导致胡须刺激期间 V2L 神经元的兴奋反应增强，触须感觉辨别能力更强。增强的跨模式反应是通过 V2L 中的小胶质细胞通过基质金属蛋白酶 9 信号传导选择性去除锥体神经元上的抑制性突触末端来介导的。我们的结果提供了关于皮质电路如何整合不同输入以功能性补偿神经元损伤的见解。
Cross-modal plasticity is the repurposing of brain regions associated with deprived sensory inputs to improve the capacity of other sensory modalities. The functional mechanisms of cross-modal plasticity can indicate how the brain recovers from various forms of injury and how different sensory modalities are integrated. Here, we demonstrate that rewiring of the microglia-mediated local circuit synapse is crucial for cross-modal plasticity induced by visual deprivation (monocular deprivation [MD]). MD relieves the usual inhibition of functional connectivity between the somatosensory cortex and secondary lateral visual cortex (V2L). This results in enhanced excitatory responses in V2L neurons during whisker stimulation and a greater capacity for vibrissae sensory discrimination. The enhanced cross-modal response is mediated by selective removal of inhibitory synapse terminals on pyramidal neurons by the microglia in the V2L via matrix metalloproteinase 9 signaling. Our results provide insights into how cortical circuits integrate different inputs to functionally compensate for neuronal damage.