Herpesviruses use bidirectional fast-axonal transport to spread in sensory neurons
Herpesviruses use bidirectional fast-axonal transport to spread in sensory neurons
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DOI：
10.1073/pnas.061029798
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发表时间：
2001-03-13
影响因子：
11.1
通讯作者：
Enquist, LW
中科院分区：
文献类型：
--
作者：
Smith, GA;Gross, SP;Enquist, LW
Alpha herpesviruses infect the vertebrate nervous system resulting in either mild recurrent lesions in mucosal epithelia or fatal encephalitis. Movement of virions within the nervous system is a critical factor in the outcome of infection; however, the dynamics of individual virion transport have never been assessed. Here we visualized and tracked individual viral capsids as they moved in axons away from infected neuronal cell bodies in culture, The observed movement was compatible with fast axonal flow mediated by multiple microtubule motors. Capsids accumulated at axon terminals, suggesting that spread from infected neurons required cell contact.
