Fast-spiking interneurons have an initial orientation bias that is lost with vision.
Fast-spiking interneurons have an initial orientation bias that is lost with vision.
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DOI：
10.1038/nn.2890
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发表时间：
2011-07-12
影响因子：
25
通讯作者：
Trachtenberg JT
中科院分区：
文献类型：
--
作者：
Kuhlman SJ;Tring E;Trachtenberg JT
我们发现，以下的眼睛开放的快速尖峰小白蛋白阳性GABA能中间神经元在小鼠有明确的方向调谐的偏好，随后的视觉体验拓宽了这种调谐。广泛的抑制调谐不需要发展锐化兴奋性调谐，但之前的双眼匹配的方向调谐。我们认为，经验依赖性的抑制扩大是一个新的候选人打开的关键期。
We find that following eye opening fast-spiking parvalbumin-positive GABAergic interneurons in mice have well-defined orientation tuning preferences and that subsequent visual experience broadens this tuning. Broad inhibitory tuning is not required for the developmental sharpening of excitatory tuning, but does precede binocular matching of orientation tuning. We propose that the experience-dependent broadening of inhibition is a novel candidate for opening the critical period.