T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides
T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides
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DOI：
10.1006/jaut.1998.0262
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发表时间：
1999-03-01
影响因子：
12.8
通讯作者：
Cohen, IR
中科院分区：
文献类型：
--
作者：
Abulafia-Lapid, R;Elias, D;Cohen, IR
T cell responses to peptide epitopes of the 60 kDa heat shock protein (hsp60) have been shown to play a role in the pathogenesis of type 1 insulin-dependent diabetes mellitus (IDDM) in mice. To test whether hsp60 autoimmunity might be involved in human type 1 diabetes, we studied T cell proliferative responses (stimulation index; SI) to intact human hsp60, to hsp60 peptides and to a recall antigen (tetanus toroid) in 25 newly diagnosed type 1 diabetes patients, in 22 type 2 (non-insulin-dependent diabetes mellitus, NIDDM) patients, and in 25 healthy blood donors. There were no significant differences between the T cell responses of the three groups to tetanus toroid. However, the responses to hsp60 of the type 1 diabetes group (median SI=5) were significantly greater (P
