Turned on to ill effect

Turned on to ill effect
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开启后效果不佳

DOI:
10.1038/365603a0
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发表时间:
1993
期刊:
影响因子:
64.8
通讯作者:
R. Lefkowitz
R. Lefkowitz
中科院分区:
综合性期刊1区
文献类型:
--
作者:
R. Lefkowitz

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讨论了G蛋白偶联受体的突变的影响,使受体组成型活性,即使在没有配体。Parma及其同事和Shenker及其同事鉴定了导致甲状腺功能亢进和家族性早熟的缺陷;受体的生理作用;突变的位置。
Discusses the effect of mutations in G-protein-coupled receptors which make the receptors constitutively active even in the absence of a ligand. Identification of defects responsible for a form of hyperthyroidism and familial precocious puberty by Parma and colleagues and Shenker and colleagues; Physiological roles of the receptor; Location of mutations.
DOI: 10.1016/s0021-9258(18)53442-6
发表时间: 1993-03
期刊: The Journal of biological chemistry
影响因子: --
作者:
P. Samama;S. Cotecchia;T. Costa;R. Lefkowitz
通讯作者: P. Samama;S. Cotecchia;T. Costa;R. Lefkowitz
DOI: 10.1073/pnas.87.8.2896
发表时间: 1990-04-01
影响因子: 11.1
作者:
COTECCHIA, S;EXUM, S;LEFKOWITZ, RJ
通讯作者: LEFKOWITZ, RJ
DOI: 10.1073/pnas.88.24.11354
发表时间: 1991-12-01
影响因子: 11.1
作者:
ALLEN, LF;LEFKOWITZ, RJ;COTECCHIA, S
通讯作者: COTECCHIA, S