A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of Brazil (Sao Goncalo do Amaranto, RN)
A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of Brazil (Sao Goncalo do Amaranto, RN)
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DOI：
10.1016/s0264-410x(00)00339-x
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发表时间：
2000-12-08
期刊：
影响因子：
5.5
通讯作者：
de Sousa, CBP
中科院分区：
文献类型：
--
作者：
da Silva, VO;Borja-Cabrera, GP;de Sousa, CBP
在流行区自然暴露的狗中研究了对犬黑热病的预防作用，这些狗接种了杜氏利什曼原虫岩藻糖甘露糖配体（FML）疫苗。接种后 7 个月，总共 97% 的疫苗接种者对 FML 呈血清反应阳性，100% 对杜氏乳杆菌裂解物表现出皮内反应。接种者的吸光度值和皮内反应的大小均显着高于对照组（方差分析，P < 0.0001）。 2 年后，实现了 92%（(2) = 6.996；P < 0.0025）的保护：只有 8% 的疫苗接种者表现出轻微的黑热病症状，没有死亡，而 33% 的对照者出现临床或致命疾病。 FML疫苗在野外对犬黑热病具有显着、持久和强大的保护作用。 (C) 2000 Elsevier Science Ltd. 保留所有权利。
Protection against canine kala-azar was investigated in naturally exposed dogs of an endemic area, vaccinated with the fucose mannose ligand (FML)-vaccine of Leishmania donovani. A total of 97% of vaccinees were seropositive to FML and 100% showed intradermal reaction to L. donovani lysate, 7 months after vaccination. The absorbency values and size of intradermal reaction were both significantly higher in vaccinees than in controls (ANOVA, P < 0.0001). After 2 years, 92% ((2) = 6.996; P < 0.0025) protection was achieved: only 8% of vaccinees showed mild signs of kala-azar with no deaths while 33% of controls developed clinical or fatal disease. The FML-vaccine induced a significant, long-lasting and strong protective effect against canine kala-azar in the field. (C) 2000 Elsevier Science Ltd. All rights reserved.