Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons
Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons
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DOI：
10.1007/s00774-010-0162-7
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发表时间：
2010-07-01
影响因子：
3.3
通讯作者：
Urade, Masahiro
中科院分区：
文献类型：
--
作者：
Yoneda, Toshiyuki;Hagino, Hiroshi;Urade, Masahiro
双膦酸盐（BPs）已广泛、有效和安全地用于治疗骨质疏松症、恶性高钙血症、实体癌骨转移和多发性骨髓瘤骨疾病。累积最近的报告描述，在接受静脉或口服BP的癌症或骨质疏松症患者中，外科牙科治疗与颌骨骨坏死（双膦酸盐相关颌骨骨坏死，BRONJ）相关。BRONJ的准确发病率、临床背景和发病机制尚不清楚，迄今为止尚未建立适当的预防和治疗方法。为了解决日本BRONJ的现状，组织了由骨生物学、整形外科、风湿病学、妇产科和内科肿瘤学专业的医生以及口腔外科、牙周病学、牙科放射学和口腔病理学专业的牙医组成的“双膦酸盐相关颌骨骨坏死联合工作组委员会”。该委员会试图提出一个标准的立场文件的治疗BRONJ。委员会希望该提案将提供关于BRONJ的客观和正确的科学信息，并将作为对接受BP的患者进行牙科手术以及设计BRONJ预防和治疗的参考。然而，由于该立场文件不是基于直接的临床证据，因此应将其用作参考，并且应在医生、牙医/口腔外科医生和患者之间进行广泛讨论后，对每种情况下的治疗做出决定。
Bisphosphonates (BPs) have been widely, efficiently, and safely used for the treatment of osteoporosis, malignant hypercalcemia, bone metastasis of solid cancers, and multiple myeloma bone diseases. Accumulating recent reports describe that surgical dental treatments in patients with cancer or osteoporosis who have been receiving intravenous or oral BPs are associated with osteonecrosis of the jaw (bisphosphonate-related osteonecrosis of the jaw, BRONJ). The accurate incidence, clinical backgrounds, and pathogenesis of BRONJ have been unclear and appropriate approaches for prevention and treatment have not been established to date. To address the current situation of BRONJ in Japan, the "Allied Task Force Committee of Bisphosphonate-Related Osteonecrosis of the Jaw," consisting of physicians specializing in bone biology, orthopedic surgery, rheumatology, obstetrics/gynecology, and medical oncology and dentists specializing in oral surgery, periodontology, dental radiology, and oral pathology, was organized. The committee attempted to propose a standard position paper for the treatment of BRONJ. The committee expects that this proposal will provide objective and correct scientific information on BRONJ and will serve as a reference for conducting dental procedures for patients receiving BPs and in designing prevention and treatment of BRONJ. However, because this position paper is not based on direct clinical evidence, it should be used as a reference, and a decision on treatment in each case should be made after an extensive discussion among physicians, dentists/oral surgeons, and the patients.