Experimental syphilis and serological examination for treponematosis in hares
Experimental syphilis and serological examination for treponematosis in hares
复制标题
野兔实验性梅毒及密螺旋体病血清学检查
DOI：
10.1128/iai.27.1.231-234.1980
复制
发表时间：
1980
影响因子：
3.1
通讯作者：
I. Rácz
中科院分区：
文献类型：
--
作者：
I. Horváth;F. Kemenes;L. Molnár;A. Széky;I. Rácz
在被研究的202只圈养野兔中，许多野兔的外生殖器受损或睾丸萎缩，或者两者兼而有之，27%的兔子梅毒血清学检测呈阳性，尽管萎缩的睾丸提取液的暗场检查为阴性。对梅毒血清学试验无反应的12只兔进行梅毒螺旋体接种，其中9只为梅毒螺旋体接种，3只为皮内接种。接种疫苗的动物中有6只在7天后出现睾丸炎，并伴有密螺旋体的堆积。在27天的观察期内，皮内接种的动物没有出现下巴。这些结果提供了更多的证据支持地方性梅毒在野兔中发生的论点，并表明野兔对实验性梅毒螺旋体感染具有适度的抵抗力。
Of 202 captive hares studied, many of which had lesions on their external genital organs or testicular atrophy or both, 27% had positive serological tests for syphilis although dark-field examination of extracts of atrophic testes was negative. A total of 12 hares that were nonreactive for the serological test for syphilis was inoculated with Treponema pallidum, 9 intratesticularly and 3 intradermally. Six of the animals inoculated intratesticularly exhibited orchitis after 7 days with an associated accumulation of treponemes. No chancres developed in the intracutaneously inoculated animals during a 27-day period of observation. These results provide additional evidence to support the contention that endemic treponematosis occurs in wild hares and suggest that hares are moderately resistant to experimental infection with T. pallidum.