IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain.

IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain.
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DOI：
10.1016/j.biopha.2022.113346
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发表时间：
2022-09
期刊：
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
影响因子：
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通讯作者：
Shuo Li;Xiao-Qin Zhang;Chuan-Chuan Liu-Chuan;Zhiyong Wang;Guan-yi Lu;Hao-Wei Shen;N. Wu;Jin Li
Shuo Li;Xiao-Qin Zhang;Chuan-Chuan Liu-Chuan;Zhiyong Wang;Guan-yi Lu;Hao-Wei Shen;N. Wu;Jin Li
中科院分区：
其他
文献类型：
--
作者：
Shuo Li;Xiao-Qin Zhang;Chuan-Chuan Liu-Chuan;Zhiyong Wang;Guan-yi Lu;Hao-Wei Shen;N. Wu;Jin Li

文献摘要

相似文献

强调siras在伏隔核中的表达调节吗啡的心理依赖。IRAS通过增强PKA的激活和AMPAR和NMDAR的磷酸化来调节谷氨酸能的传递。IRAS参与AMPA受体拮抗剂抑制吗啡依赖的作用。
HighlightsIRAS expression in the nucleus accumbens regulates morphine psychological dependence.IRAS modulates glutamatergic transmission through the enhanced PKA activation and phosphorylation of AMPAR and NMDAR.IRAS participates in the effect of AMPA receptor antagonist on inhibiting morphine dependence.