Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis
Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis
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DOI：
10.1016/j.jneuroim.2015.02.004
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发表时间：
2015-04-15
影响因子：
3.3
通讯作者：
Harirchian, Mohammad Hossein
中科院分区：
文献类型：
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作者：
Aleagha, Mohammad Sajad Emami;Siroos, Bahaadin;Harirchian, Mohammad Hossein
最近的研究支持一种抗衰老蛋白，即Klotho，保护神经元免受氧化应激和脱髓鞘。我们评估了复发-缓解型多发性硬化症（RRMS）患者脑脊液（CSF）中Klotho蛋白浓度和总抗氧化能力（TAC）。与对照组相比，患者的Klotho浓度和TAC显著降低。Klotho值与扩展残疾状态量表（EDSS）呈显著负相关。此外，TAC水平与Klotho浓度呈显著正相关。Klotho可能通过调控氧化还原系统在MS的发病机制中发挥重要作用。(C) 2015 Elsevier B.V.版权所有
Recent investigations support that an anti-aging protein, namely Klotho, protects neurons against the oxidative stress and demyelination. We evaluated the protein concentration of Klotho and total anti-oxidant capacity (TAC) in the cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (RRMS). Klotho concentration and TAC were significantly lower in patients as compared to controls. Klotho values showed a significant negative correlation with expanded disability status scale (EDSS). Moreover, a significantly positive correlation between TAC levels and Klotho concentrations was detected. Klotho may play an important role in the pathogenesis of MS, at least in part, through the regulation of redox system. (C) 2015 Elsevier B.V. All rights reserved.