c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration
c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration
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DOI：
10.1016/j.febslet.2009.11.009
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发表时间：
2010-01-04
期刊：
影响因子：
3.5
通讯作者：
Berton, Giorgio
中科院分区：
文献类型：
--
作者：
Baruzzi, Anna;Iacobucci, Ilaria;Berton, Giorgio
细胞骨架动力学受Src家族酪氨酸激酶（SFKs）和c-Abl的调节，在小鼠巨噬细胞中，SFK成员Hck和c-Fgr调节c-Abl的酪氨酸磷酸化，c-Abl与β 1整合素结合的Hck或c-Fgr结合。用选择性抑制剂和来自SFK缺陷小鼠的细胞的研究表明，c-Abl和SFK调节巨噬细胞中小GTP酶Cdc 42和Rac的迁移和活化。此外，c-Abl抑制剂降低了人中性粒细胞的趋化活性，慢性粒细胞白血病患者的中性粒细胞表现出增加的趋化能力。因此，Src家族激酶和c-Abl在髓样细胞迁移的调节中相互作用。
Cytoskeleton dynamics are regulated by Src-family tyrosine kinases (SFKs) and c-Abl. We found that the SFK members Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with beta 1 integrin-bound Hck or c-Fgr in murine macrophages. Studies with selective inhibitors and cells from SFK-deficient mice showed that c-Abl and SFK regulate migration and activation of the small GTPases Cdc42 and Rac in macrophages. Additionally, human neutrophil chemotactic activity was reduced by c-Abl inhibitors, and neutrophils from chronic myeloid leukaemia patients displayed an increased chemotactic ability. Hence, Src-family kinase and c-Abl cross-talk in the regulation of myeloid cell migration.